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Dhvanit I Shah, PhD
Associate Scientist, Brigham and Women's Hospital
Instructor in Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

Research Location: Karp Childrens Hospital Research Building

Research Email:

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Research Narrative:

The use of hematopoietic stem cells (HSCs) transplant, for the treatment of bone marrow failure syndromes and leukemia, is limited due to the availability of matching donor(s) and/or numbers of HSCs. To circumvent these issues, we are analyzing new sources and factors regulating emergence and development of HSCs from hemogenic endothelium. We have identified cell-intrinsic and cell-extrinsic factors that stimulate HSC production from endothelial cells. We expect to establish a new recipe to stimulate HSCs from hemogenic endothelial cells. The long term goal of our study is to regenerate patient-derived hemogenic endothelial cells for the treatment of patients with genetic blood disorders and cancers.

Harvard Medical School, 2010, Postdoctoral Fellow
Punjabi University, 2006, Ph.D.
Gujarat University, 2003, M.Pharm.
Gujarat University, 2001, B.Pharm.

Lab Members:

Taylor Patch, Lab Manager

Jennifer Cillis, Research Technician

Caitlyn Curley, Research Technician