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Dhvanit I Shah, PhD
Associate Scientist, Brigham and Women's Hospital
Instructor in Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Hematology
75 Francis Street
Boston, MA 02115

Research Location: Karp Childrens Hospital Research Building

Research Email: dshah@research.bwh.harvard.edu

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Research Narrative:

The use of hematopoietic stem cells (HSCs) transplant, for the treatment of bone marrow failure syndromes and leukemia, is limited due to the availability of matching donor(s) and/or numbers of HSCs. To circumvent these issues, we are analyzing new sources and factors regulating emergence and development of HSCs from hemogenic endothelium. We have identified cell-intrinsic and cell-extrinsic factors that stimulate HSC production from endothelial cells. We expect to establish a new recipe to stimulate HSCs from hemogenic endothelial cells. The long term goal of our study is to regenerate patient-derived hemogenic endothelial cells for the treatment of patients with genetic blood disorders and cancers.


Education:
Harvard Medical School, 2010, Postdoctoral Fellow
Punjabi University, 2006, Ph.D.
Gujarat University, 2003, M.Pharm.
Gujarat University, 2001, B.Pharm.

Lab Members:

Taylor Patch, Lab Manager

Jennifer Cillis, Research Technician

Caitlyn Curley, Research Technician