Skip to contents
Howard D. Sesso, SCD, MPH
Associate Epidemiologist, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Preventive Medicine
75 Francis Street
Boston, MA 02115


Edit Profile


Research Narrative:

Dr. Sesso's primary research is in the epidemiology and prevention of cardiovascular disease (CVD), especially hypertension. He is particularly interested in the relation of physical activity, obesity, and dietary factors such as antioxidant vitamins, lycopene, strawberries, and flavonoids to CVD and hypertension, as well as the role of novel biomarkers that underlie these associations. He is Co-Director of Hypertension Research in the Division of Preventive Medicine, having led the identification and validation of hypertension as an endpoint in the Women's Health Study (WHS) and Physicians' Health Study (PHS). He has received grants to examine novel biochemical and genetic markers of incident hypertension in the WHS, PHS, and Women’s Health Initiative. He is also Director of Nutrition Research in the Division, with several grants and publications in this area. Dr. Sesso’s most recent grant will allow him to examine the relation between physical activity, diet, and the onset of obesity in the WHS, PHS, and the Harvard Alumni Study. In collaboration with the Division of Cardiology, Dr. Sesso has also recently initiated clinical trials to test the role of lycopene and lutein supplements on the progression of carotid atherosclerosis and changes in coronary biomarkers in individuals with coronary heart disease.


Education:
Harvard School of Public Health , 1999, SCD
George Washington University, 1995, MPH

Publications (Pulled from Harvard Catalyst Profiles):

1. Matsumoto C, Yoruk A, Wang L, Gaziano JM, Sesso HD. Fish and omega-3 fatty acid consumption and risk of hypertension. J Hypertens. 2019 Mar 14.

2. Hall KT, Buring JE, Mukamal KJ, Vinayaga Moorthy M, Wayne PM, Kaptchuk TJ, Battinelli EM, Ridker PM, Sesso HD, Weinstein SJ, Albanes D, Cook NR, Chasman DI. COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials. J Natl Cancer Inst. 2019 Jan 08.

3. Muller DC, Larose TL, Hodge A, Guida F, Langhammer A, Grankvist K, Meyer K, Cai Q, Arslan AA, Zeleniuch-Jacquotte A, Albanes D, Giles GG, Sesso HD, Lee IM, Gaziano JM, Yuan JM, Hoffman Bolton J, Buring JE, Visvanathan K, Le Marchand L, Purdue MP, Caporaso NE, Midttun Ø, Ueland PM, Prentice RL, Weinstein SJ, Stevens VL, Zheng W, Blot WJ, Shu XO, Zhang X, Xiang YB, Koh WP, Hveem K, Thomson CA, Pettinger M, Engström G, Brunnström H, Milne RL, Stampfer MJ, Han J, Johansson M, Brennan P, Severi G, Johansson M. Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium. BMJ. 2019 01 03; 364:k4981.

4. Johansson M, Carreras-Torres R, Scelo G, Purdue MP, Mariosa D, Muller DC, Timpson NJ, Haycock PC, Brown KM, Wang Z, Ye Y, Hofmann JN, Foll M, Gaborieau V, Machiela MJ, Colli LM, Li P, Garnier JG, Blanche H, Boland A, Burdette L, Prokhortchouk E, Skryabin KG, Yeager M, Radojevic-Skodric S, Ognjanovic S, Foretova L, Holcatova I, Janout V, Mates D, Mukeriya A, Rascu S, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Benhamou S, Cancel-Tassin G, Cussenot O, Weiderpass E, Ljungberg B, Tumkur Sitaram R, Häggström C, Bruinsma F, Jordan SJ, Severi G, Winship I, Hveem K, Vatten LJ, Fletcher T, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Andreotti G, Beane Freeman LE, Koutros S, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Gapstur SM, Stevens VL, Carol H, Freedman ML, Pomerantz MM, Cho E, Wilson KM, Gaziano JM, Sesso HD, Freedman ND, Parker AS, Eckel-Passow JE, Huang WY, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Buring J, Lee IM, Chow WH, Moore LE, Eisen T, Henrion M, Larkin J, Barman P, Leibovich BC, Choueiri TK, Lathrop GM, Deleuze JF, Gunter M, McKay JD, Wu X, Houlston RS, Chanock SJ, Relton C, Richards JB, Martin RM, Davey Smith G, Brennan P. The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study. PLoS Med. 2019 Jan; 16(1):e1002724.

5. Ahearn TU, Peisch S, Pettersson A, Ebot EM, Zhou CK, Graff RE, Sinnott JA, Fazli L, Judson GL, Bismar TA, Rider JR, Gerke T, Chan JM, Fiorentino M, Flavin R, Sesso HD, Finn S, Giovannucci EL, Gleave M, Loda M, Li Z, Pollak M, Mucci LA. Expression of IGF/insulin receptor in prostate cancer tissue and progression to lethal disease. Carcinogenesis. 2018 Dec 31; 39(12):1431-1437.

6. Walsh N, Zhang H, Hyland PL, Yang Q, Mocci E, Zhang M, Childs EJ, Collins I, Wang Z, Arslan AA, Beane-Freeman L, Bracci PM, Brennan P, Canzian F, Duell EJ, Gallinger S, Giles GG, Goggins M, Goodman GE, Goodman PJ, Hung RJ, Kooperberg C, Kurtz RC, Malats N, LeMarchand L, Neale RE, Olson SH, Scelo G, Shu XO, Van Den Eeden SK, Visvanathan K, White E, Zheng W, Albanes D, Andreotti G, Babic A, Bamlet WR, Berndt SI, Borgida A, Boutron-Ruault MC, Brais L, Brennan P, Bueno-de-Mesquita B, Buring J, Chaffee KG, Chanock S, Cleary S, Cotterchio M, Foretova L, Fuchs C, M Gaziano JM, Giovannucci E, Goggins M, Hackert T, Haiman C, Hartge P, Hasan M, Helzlsouer KJ, Herman J, Holcatova I, Holly EA, Hoover R, Hung RJ, Janout V, Klein EA, Kurtz RC, Laheru D, Lee IM, Lu L, Malats N, Mannisto S, Milne RL, Oberg AL, Orlow I, Patel AV, Peters U, Porta M, Real FX, Rothman N, Sesso HD, Severi G, Silverman D, Strobel O, Sund M, Thornquist MD, Tobias GS, Wactawski-Wende J, Wareham N, Weiderpass E, Wentzensen N, Wheeler W, Yu H, Zeleniuch-Jacquotte A, Kraft P, Li D, Jacobs EJ, Petersen GM, Wolpin BM, Risch HA, Amundadottir LT, Yu K, Klein AP, Stolzenberg-Solomon RZ. Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer. J Natl Cancer Inst. 2018 Dec 12.

7. Russ TC, Lee IM, Sesso HD, Muniz-Terrera G, Batty GD. Five-decade trajectories in body mass index in relation to dementia death: follow-up of 33,083 male Harvard University alumni. Int J Obes (Lond). 2018 Dec 11.

8. Larose TL, Guida F, Fanidi A, Langhammer A, Kveem K, Stevens VL, Jacobs EJ, Smith-Warner SA, Giovannucci E, Albanes D, Weinstein SJ, Freedman ND, Prentice R, Pettinger M, Thomson CA, Cai Q, Wu J, Blot WJ, Arslan AA, Zeleniuch-Jacquotte A, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Stampfer MJ, Hodge AM, Giles GG, Severi G, Johansson M, Grankvist K, Wang R, Yuan JM, Gao YT, Koh WP, Shu XO, Zheng W, Xiang YB, Li H, Lan Q, Visvanathan K, Hoffman Bolton J, Ueland PM, Midttun Ø, Caporaso N, Purdue M, Sesso HD, Buring JE, Lee IM, Gaziano JM, Manjer J, Brunnström H, Brennan P, Johansson M. Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). Int J Epidemiol. 2018 12 01; 47(6):1760-1771.

9. Fanidi A, Carreras-Torres R, Larose TL, Yuan JM, Stevens VL, Weinstein SJ, Albanes D, Prentice R, Pettinger M, Cai Q, Blot WJ, Arslan AA, Zeleniuch-Jacquotte A, McCullough ML, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Stampfer MJ, Smith-Warner SA, Giovannucci E, Giles GG, Hodge AM, Severi G, Johansson M, Grankvist K, Langhammer A, Brumpton BM, Wang R, Gao YT, Ericson U, Bojesen SE, Arnold SM, Koh WP, Shu XO, Xiang YB, Li H, Zheng W, Lan Q, Visvanathan K, Hoffman-Bolton J, Ueland PM, Midttun Ø, Caporaso NE, Purdue M, Freedman ND, Buring JE, Lee IM, Sesso HD, Michael Gaziano J, Manjer J, Relton CL, Hung RJ, Amos CI, Johansson M, Brennan P. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2018 Nov 29.

10. Sotos-Prieto M, Mattei J, Cook NR, Hu FB, Willett WC, Chiuve SE, Rimm EB, Sesso HD. Association Between a 20-Year Cardiovascular Disease Risk Score Based on Modifiable Lifestyles and Total and Cause-Specific Mortality Among US Men and Women. J Am Heart Assoc. 2018 Nov 06; 7(21):e010052.