Howard D. Sesso, SCD, MPH - Department of Medicine

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Howard D. Sesso, SCD, MPH

Associate Epidemiologist, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Preventive Medicine
75 Francis Street
Boston, MA 02115

Research Narrative: Dr. Sesso's primary research is in the epidemiology and prevention of cardiovascular disease (CVD), especially hypertension. He is particularly interested in the relation of physical activity, obesity, and dietary factors such as antioxidant vitamins, lycopene, strawberries, and flavonoids to CVD and hypertension, as well as the role of novel biomarkers that underlie these associations. He is Co-Director of Hypertension Research in the Division of Preventive Medicine, having led the identification and validation of hypertension as an endpoint in the Women's Health Study (WHS) and Physicians' Health Study (PHS). He has received grants to examine novel biochemical and genetic markers of incident hypertension in the WHS, PHS, and Women’s Health Initiative. He is also Director of Nutrition Research in the Division, with several grants and publications in this area. Dr. Sesso’s most recent grant will allow him to examine the relation between physical activity, diet, and the onset of obesity in the WHS, PHS, and the Harvard Alumni Study. In collaboration with the Division of Cardiology, Dr. Sesso has also recently initiated clinical trials to test the role of lycopene and lutein supplements on the progression of carotid atherosclerosis and changes in coronary biomarkers in individuals with coronary heart disease.

Education:	Harvard School of Public Health , 1999, SCD George Washington University, 1995, MPH

Keywords (MeSH):	Lycopersicon esculentum Flavonoids Vitamins Hypertension Carotenoids Cardiovascular Diseases Antioxidants Alcohol Drinking

Publications (Pulled from Harvard Catalyst Profiles): 1. Gaziano JM, Sesso HD. Multivitamins for cancer prevention in men-reply. JAMA. 2013 Mar 13; 309(10):980-1. 2. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design. Cancer Causes Control. 2013 Apr; 24(4):695-704. 3. Song Y, Chavarro JE, Cao Y, Qiu W, Mucci L, Sesso HD, Stampfer MJ, Giovannucci E, Pollak M, Liu S, Ma J. Whole Milk Intake Is Associated with Prostate Cancer-Specific Mortality among U.S. Male Physicians. J Nutr. 2013 Feb; 143(2):189-96. 4. Bao Y, Giovannucci EL, Kraft P, Stampfer MJ, Ogino S, Ma J, Buring JE, Sesso HD, Lee IM, Gaziano JM, Rifai N, Pollak MN, Cochrane BB, Kaklamani V, Lin JH, Manson JE, Fuchs CS, Wolpin BM. A Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US Cohorts. J Natl Cancer Inst. 2013 Jan 16; 105(2):95-103. 5. Eliassen AH, Hendrickson SJ, Brinton LA, Buring JE, Campos H, Dai Q, Dorgan JF, Franke AA, Gao YT, Goodman MT, Hallmans G, Helzlsouer KJ, Hoffman-Bolton J, Hultén K, Sesso HD, Sowell AL, Tamimi RM, Toniolo P, Wilkens LR, Winkvist A, Zeleniuch-Jacquotte A, Zheng W, Hankinson SE. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. J Natl Cancer Inst. 2012 Dec 19; 104(24):1905-16. 6. Gaziano JM, Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, Schvartz M, Manson JE, Glynn RJ, Buring JE. Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2012 Nov 14; 308(18):1871-80. 7. Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, Schvartz M, Manson JE, Glynn RJ, Buring JE, Gaziano JM. Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2012 Nov 7; 308(17):1751-60. 8. Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, Lundqvist A, Jassal SK, Barrett-Connor E, Zhang C, Eaton CB, May HT, Anderson JL, Sesso HD. Circulating 25-hydroxy-vitamin d and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012 Nov 1; 5(6):819-29. 9. Whitley E, Lee IM, Sesso HD, Batty GD. Association of cigarette smoking from adolescence to middle-age with later total and cardiovascular disease mortality: the harvard alumni health study. J Am Coll Cardiol. 2012 Oct 30; 60(18):1839-40. 10. Rajaraman P, Melin BS, Wang Z, McKean-Cowdin R, Michaud DS, Wang SS, Bondy M, Houlston R, Jenkins RB, Wrensch M, Yeager M, Ahlbom A, Albanes D, Andersson U, Freeman LE, Buring JE, Butler MA, Braganza M, Carreon T, Feychting M, Fleming SJ, Gapstur SM, Gaziano JM, Giles GG, Hallmans G, Henriksson R, Hoffman-Bolton J, Inskip PD, Johansen C, Kitahara CM, Lathrop M, Liu C, Le Marchand L, Linet MS, Lonn S, Peters U, Purdue MP, Rothman N, Ruder AM, Sanson M, Sesso HD, Severi G, Shu XO, Simon M, Stampfer M, Stevens VL, Visvanathan K, White E, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Decker P, Enciso-Mora V, Fridley B, Gao YT, Kosel M, Lachance DH, Lau C, Rice T, Swerdlow A, Wiemels JL, Wiencke JK, Shete S, Xiang YB, Xiao Y, Hoover RN, Fraumeni JF, Chatterjee N, Hartge P, Chanock SJ. Genome-wide association study of glioma and meta-analysis. Hum Genet. 2012 Dec; 131(12):1877-88. show all 11. Winter AC, Wang L, Buring JE, Sesso HD, Kurth T. Migraine, weight gain and the risk of becoming overweight and obese: a prospective cohort study. Cephalalgia. 2012 Oct; 32(13):963-71. 12. Wang L, Manson JE, Gaziano JM, Liu S, Cochrane B, Cook NR, Ridker PM, Rifai N, Sesso HD. Plasma adiponectin and the risk of hypertension in white and black postmenopausal women. Clin Chem. 2012 Oct; 58(10):1438-45. 13. Kitahara CM, Wang SS, Melin BS, Wang Z, Braganza M, Inskip PD, Albanes D, Andersson U, Beane Freeman LE, Buring JE, Carreón T, Feychting M, Gapstur SM, Gaziano JM, Giles GG, Hallmans G, Hankinson SE, Henriksson R, Hsing AW, Johansen C, Linet MS, McKean-Cowdin R, Michaud DS, Peters U, Purdue MP, Rothman N, Ruder AM, Sesso HD, Severi G, Shu XO, Stevens VL, Visvanathan K, Waters MA, White E, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Hoover R, Fraumeni JF, Chatterjee N, Yeager M, Chanock SJ, Hartge P, Rajaraman P. Association between adult height, genetic susceptibility and risk of glioma. Int J Epidemiol. 2012 Aug; 41(4):1075-85. 14. Pettersson A, Graff RE, Bauer SR, Pitt MJ, Lis RT, Stack EC, Martin NE, Kunz L, Penney KL, Ligon AH, Suppan C, Flavin R, Sesso HD, Rider JR, Sweeney C, Stampfer MJ, Fiorentino M, Kantoff PW, Sanda MG, Giovannucci EL, Ding EL, Loda M, Mucci LA. The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2012 Sep; 21(9):1497-509. 15. Lee IM, Sesso HD, Ridker PM, Mouton CP, Stefanick ML, Manson JE. Physical activity and inflammation in a multiethnic cohort of women. Med Sci Sports Exerc. 2012 Jun; 44(6):1088-96. 16. Christen WG, Glynn RJ, Sesso HD, Kurth T, Macfadyen J, Bubes V, Buring JE, Manson JE, Gaziano JM. Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians. Ophthalmology. 2012 Aug; 119(8):1642-9. 17. Rahilly-Tierney C, Sesso HD, Michael Gaziano J, Djoussé L. High-density lipoprotein and mortality before age 90 in male physicians. Circ Cardiovasc Qual Outcomes. 2012 May; 5(3):381-6. 18. Wang L, Manson JE, Sesso HD. Calcium intake and risk of cardiovascular disease: a review of prospective studies and randomized clinical trials. Am J Cardiovasc Drugs. 2012 Apr 1; 12(2):105-16. 19. Shiroma EJ, Sesso HD, Lee IM. Physical activity and weight gain prevention in older men. Int J Obes (Lond). 2012 Sep; 36(9):1165-9. 20. Sesso HD, Wang L, Ridker PM, Buring JE. Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women. J Nutr. 2012 Feb; 142(2):326-33. 21. Britton KA, Lee IM, Wang L, Gaziano JM, Manson JE, Buring JE, Sesso HD. Physical activity and the risk of becoming overweight or obese in middle-aged and older women. Obesity (Silver Spring). 2012 May; 20(5):1096-103. 22. Gray L, Lee IM, Sesso HD, Batty GD. Blood pressure in early adulthood, hypertension in middle age, and future cardiovascular disease mortality: HAHS (Harvard Alumni Health Study). J Am Coll Cardiol. 2011 Nov 29; 58(23):2396-403. 23. Cao Y, Kenfield S, Song Y, Rosner B, Qiu W, Sesso HD, Gaziano JM, Ma J. Cigarette smoking cessation and total and cause-specific mortality: a 22-year follow-up study among US male physicians. Arch Intern Med. 2011 Nov 28; 171(21):1956-9. 24. Wolpin BM, Ng K, Bao Y, Kraft P, Stampfer MJ, Michaud DS, Ma J, Buring JE, Sesso HD, Lee IM, Rifai N, Cochrane BB, Wactawski-Wende J, Chlebowski RT, Willett WC, Manson JE, Giovannucci EL, Fuchs CS. Plasma 25-hydroxyvitamin D and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2012 Jan; 21(1):82-91. 25. Margalit DN, Kasperzyk JL, Martin NE, Sesso HD, Gaziano JM, Ma J, Stampfer MJ, Mucci LA. Beta-carotene antioxidant use during radiation therapy and prostate cancer outcome in the Physicians' Health Study. Int J Radiat Oncol Biol Phys. 2012 May 1; 83(1):28-32. 26. Gray L, Lee IM, Sesso HD, Batty GD. Body weight in early and mid-adulthood in relation to subsequent coronary heart disease mortality: 80-year follow-up in the Harvard Alumni Study. Arch Intern Med. 2011 Oct 24; 171(19):1768-70; discussion 1770. 27. Wang L, Manson JE, Gaziano JM, Buring JE, Sesso HD. Fruit and vegetable intake and the risk of hypertension in middle-aged and older women. Am J Hypertens. 2012 Feb; 25(2):180-9. 28. Dhillon PK, Penney KL, Schumacher F, Rider JR, Sesso HD, Pollak M, Fiorentino M, Finn S, Loda M, Rifai N, Mucci LA, Giovannucci E, Stampfer MJ, Ma J. Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2011 Dec; 20(12):2618-27. 29. Wang L, Tsai M, Manson JE, Djousse L, Gaziano JM, Buring JE, Sesso HD. Erythrocyte fatty acid composition is associated with the risk of hypertension in middle-aged and older women. J Nutr. 2011 Sep; 141(9):1691-7. 30. Paynter NP, Sesso HD, Conen D, Otvos JD, Mora S. Lipoprotein subclass abnormalities and incident hypertension in initially healthy women. Clin Chem. 2011 Aug; 57(8):1178-87. 31. Gray L, Lee IM, Sesso HD, Batty GD. Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: the Harvard Alumni Health Study. Ann Oncol. 2012 Mar; 23(3):754-9. 32. Shui IM, Stark JR, Penney KL, Schumacher FR, Epstein MM, Pitt MJ, Stampfer MJ, Tamimi RM, Lindstrom S, Sesso HD, Fall K, Ma J, Kraft P, Giovannucci E, Mucci LA. Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality. Prostate. 2012 Feb 1; 72(2):209-16. 33. Penney KL, Sinnott JA, Fall K, Pawitan Y, Hoshida Y, Kraft P, Stark JR, Fiorentino M, Perner S, Finn S, Calza S, Flavin R, Freedman ML, Setlur S, Sesso HD, Andersson SO, Martin N, Kantoff PW, Johansson JE, Adami HO, Rubin MA, Loda M, Golub TR, Andrén O, Stampfer MJ, Mucci LA. mRNA expression signature of Gleason grade predicts lethal prostate cancer. J Clin Oncol. 2011 Jun 10; 29(17):2391-6. 34. Rahilly-Tierney C, Sesso HD, Djoussé L, Gaziano JM. Lifestyle changes and 14-year change in high-density lipoprotein cholesterol in a cohort of male physicians. Am Heart J. 2011 Apr; 161(4):712-8. 35. Penney KL, Schumacher FR, Kraft P, Mucci LA, Sesso HD, Ma J, Niu Y, Cheong JK, Hunter DJ, Stampfer MJ, Hsu SI. Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels. Carcinogenesis. 2011 Jun; 32(6):853-9. 36. Wang L, Manson JE, Gaziano JM, Liu S, Cochrane B, Cook NR, Ridker PM, Rifai N, Sesso HD. Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal women. Clin Chem. 2011 May; 57(5):729-36. 37. Britton KA, Pradhan AD, Gaziano JM, Manson JE, Ridker PM, Buring JE, Sesso HD. Hemoglobin A1c, body mass index, and the risk of hypertension in women. Am J Hypertens. 2011 Mar; 24(3):328-34. 38. Berrington de Gonzalez A, Hartge P, Cerhan JR, Flint AJ, Hannan L, MacInnis RJ, Moore SC, Tobias GS, Anton-Culver H, Freeman LB, Beeson WL, Clipp SL, English DR, Folsom AR, Freedman DM, Giles G, Hakansson N, Henderson KD, Hoffman-Bolton J, Hoppin JA, Koenig KL, Lee IM, Linet MS, Park Y, Pocobelli G, Schatzkin A, Sesso HD, Weiderpass E, Willcox BJ, Wolk A, Zeleniuch-Jacquotte A, Willett WC, Thun MJ. Body-mass index and mortality among 1.46 million white adults. N Engl J Med. 2010 Dec 2; 363(23):2211-9. 39. Sesso HD. How should we conduct studies on interventions that promote clinically relevant increases in physical activity? Rev Esp Cardiol. 2010 Nov; 63(11):1232-4. 40. Christen WG, Glynn RJ, Sesso HD, Kurth T, MacFadyen J, Bubes V, Buring JE, Manson JE, Gaziano JM. Age-related cataract in a randomized trial of vitamins E and C in men. Arch Ophthalmol. 2010 Nov; 128(11):1397-405. 41. Terry PD, Glynn RJ, Buring JE, Sesso HD. Hypertension and risk of death from external causes in the Physicians' Health Study enrollment cohort. Int J Public Health. 2011 Apr; 56(2):231-5. 42. Wang L, Manson JE, Forman JP, Gaziano JM, Buring JE, Sesso HD. Dietary fatty acids and the risk of hypertension in middle-aged and older women. Hypertension. 2010 Oct; 56(4):598-604. 43. Meyer MS, Penney KL, Stark JR, Schumacher FR, Sesso HD, Loda M, Fiorentino M, Finn S, Flavin RJ, Kurth T, Price AL, Giovannucci EL, Fall K, Stampfer MJ, Ma J, Mucci LA. Genetic variation in RNASEL associated with prostate cancer risk and progression. Carcinogenesis. 2010 Sep; 31(9):1597-603. 44. Fiorentino M, Judson G, Penney K, Flavin R, Stark J, Fiore C, Fall K, Martin N, Ma J, Sinnott J, Giovannucci E, Stampfer M, Sesso HD, Kantoff PW, Finn S, Loda M, Mucci L. Immunohistochemical expression of BRCA1 and lethal prostate cancer. Cancer Res. 2010 Apr 15; 70(8):3136-9. 45. Lee IM, Djoussé L, Sesso HD, Wang L, Buring JE. Physical activity and weight gain prevention. JAMA. 2010 Mar 24; 303(12):1173-9. 46. Wang L, Lee IM, Manson JE, Buring JE, Sesso HD. Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older women. Arch Intern Med. 2010 Mar 8; 170(5):453-61. 47. Wang L, Manson JE, Song Y, Sesso HD. Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med. 2010 Mar 2; 152(5):315-23. 48. Siegel LC, Sesso HD, Bowman TS, Lee IM, Manson JE, Gaziano JM. Physical activity, body mass index, and diabetes risk in men: a prospective study. Am J Med. 2009 Dec; 122(12):1115-21. 49. Lee IM, Ewing R, Sesso HD. The built environment and physical activity levels: the Harvard Alumni Health Study. Am J Prev Med. 2009 Oct; 37(4):293-8. 50. Britton KA, Gaziano JM, Sesso HD, Djoussé L. Relation of alcohol consumption and coronary heart disease in hypertensive male physicians (from the Physicians' Health Study). Am J Cardiol. 2009 Oct 1; 104(7):932-5. 51. Paynter NP, Cook NR, Everett BM, Sesso HD, Buring JE, Ridker PM. Prediction of incident hypertension risk in women with currently normal blood pressure. Am J Med. 2009 May; 122(5):464-71. 52. Wang L, Lee IM, Zhang SM, Blumberg JB, Buring JE, Sesso HD. Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women. Am J Clin Nutr. 2009 Mar; 89(3):905-12. 53. Kenchaiah S, Sesso HD, Gaziano JM. Body mass index and vigorous physical activity and the risk of heart failure among men. Circulation. 2009 Jan 6; 119(1):44-52. 54. Rahilly-Tierney C, Bowman TS, Djoussé L, Sesso HD, Gaziano JM. Change in high-density lipoprotein cholesterol and incident coronary heart disease in apparently healthy male physicians. Am J Cardiol. 2008 Dec 15; 102(12):1663-7. 55. Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Sesso HD, Buring JE. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2009 Jan 7; 301(1):52-62. 56. Jenkins DJ, Nguyen TH, Kendall CW, Faulkner DA, Bashyam B, Kim IJ, Ireland C, Patel D, Vidgen E, Josse AR, Sesso HD, Burton-Freeman B, Josse RG, Leiter LA, Singer W. The effect of strawberries in a cholesterol-lowering dietary portfolio. Metabolism. 2008 Dec; 57(12):1636-44. 57. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RJ, Gaziano JM. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2008 Nov 12; 300(18):2123-33. 58. Chavarro JE, Stampfer MJ, Hall MN, Sesso HD, Ma J. A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality. Am J Clin Nutr. 2008 Nov; 88(5):1297-303. 59. Wang L, Gaziano JM, Norkus EP, Buring JE, Sesso HD. Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women. Am J Clin Nutr. 2008 Sep; 88(3):747-54. 60. Weinstein AR, Sesso HD, Lee IM, Rexrode KM, Cook NR, Manson JE, Buring JE, Gaziano JM. The joint effects of physical activity and body mass index on coronary heart disease risk in women. Arch Intern Med. 2008 Apr 28; 168(8):884-90. 61. Farwell WR, Michael Gaziano J, Norkus EP, Sesso HD. The relationship between total plasma carotenoids and risk factors for chronic disease among middle-aged and older men. Br J Nutr. 2008 Oct; 100(4):883-9. 62. Dhingra R, Sesso HD, Kenchaiah S, Gaziano JM. Differential effects of lipids on the risk of heart failure and coronary heart disease: the Physicians' Health Study. Am Heart J. 2008 May; 155(5):869-75. 63. Wang L, Manson JE, Buring JE, Lee IM, Sesso HD. Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension. 2008 Apr; 51(4):1073-9. 64. Sesso HD, Cook NR, Buring JE, Manson JE, Gaziano JM. Alcohol consumption and the risk of hypertension in women and men. Hypertension. 2008 Apr; 51(4):1080-7. 65. Wang L, Manson JE, Buring JE, Sesso HD. Meat intake and the risk of hypertension in middle-aged and older women. J Hypertens. 2008 Feb; 26(2):215-22. 66. Halperin RO, Gaziano JM, Sesso HD. Smoking and the risk of incident hypertension in middle-aged and older men. Am J Hypertens. 2008 Feb; 21(2):148-52. 67. Bowman TS, Gaziano JM, Buring JE, Sesso HD. A prospective study of cigarette smoking and risk of incident hypertension in women. J Am Coll Cardiol. 2007 Nov 20; 50(21):2085-92. 68. Logroscino G, Sesso HD, Paffenbarger RS, Lee IM. Body mass index and risk of Parkinson's disease: a prospective cohort study. Am J Epidemiol. 2007 Nov 15; 166(10):1186-90. 69. Sesso HD, Gaziano JM, Jenkins DJ, Buring JE. Strawberry intake, lipids, C-reactive protein, and the risk of cardiovascular disease in women. J Am Coll Nutr. 2007 Aug; 26(4):303-10. 70. Wang L, Gaziano JM, Liu S, Manson JE, Buring JE, Sesso HD. Whole- and refined-grain intakes and the risk of hypertension in women. Am J Clin Nutr. 2007 Aug; 86(2):472-9. 71. Bowman TS, Kurth T, Sesso HD, Manson JE, Gaziano JM. Eight-year change in body mass index and subsequent risk of cardiovascular disease among healthy non-smoking men. Prev Med. 2007 Dec; 45(6):436-41. 72. Sesso HD. Invited commentary: a challenge for physical activity epidemiology. Am J Epidemiol. 2007 Jun 15; 165(12):1351-3; discussion 1354-5. 73. Gelber RP, Gaziano JM, Manson JE, Buring JE, Sesso HD. A prospective study of body mass index and the risk of developing hypertension in men. Am J Hypertens. 2007 Apr; 20(4):370-7. 74. Hall MN, Campos H, Li H, Sesso HD, Stampfer MJ, Willett WC, Ma J. Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2007 Feb; 16(2):314-21. 75. Sesso HD, Wang L, Buring JE, Ridker PM, Gaziano JM. Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women. Hypertension. 2007 Feb; 49(2):304-10. 76. Koh KA, Sesso HD, Paffenbarger RS, Lee IM. Dairy products, calcium and prostate cancer risk. Br J Cancer. 2006 Dec 4; 95(11):1582-5. 77. Song Y, Sesso HD, Manson JE, Cook NR, Buring JE, Liu S. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Am J Cardiol. 2006 Dec 15; 98(12):1616-21. 78. Koushik A, Tranah GJ, Ma J, Stampfer MJ, Sesso HD, Fuchs CS, Giovannucci EL, Hunter DJ. p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer. Int J Cancer. 2006 Oct 15; 119(8):1863-8. 79. Bowman TS, Gaziano JM, Kase CS, Sesso HD, Kurth T. Blood pressure measures and risk of total, ischemic, and hemorrhagic stroke in men. Neurology. 2006 Sep 12; 67(5):820-3. 80. Logroscino G, Sesso HD, Paffenbarger RS, Lee IM. Physical activity and risk of Parkinson's disease: a prospective cohort study. J Neurol Neurosurg Psychiatry. 2006 Dec; 77(12):1318-22. 81. Wang L, Liu S, Pradhan AD, Manson JE, Buring JE, Gaziano JM, Sesso HD. Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women. Am J Epidemiol. 2006 Sep 15; 164(6):576-85. 82. Bowman TS, Gaziano JM, Stampfer MJ, Sesso HD. Homocysteine and risk of developing hypertension in men. J Hum Hypertens. 2006 Aug; 20(8):631-4. 83. Wang L, Liu S, Manson JE, Gaziano JM, Buring JE, Sesso HD. The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in women. J Nutr. 2006 Mar; 136(3):620-5. 84. Kaplowitz RA, Scranton RE, Gagnon DR, Cantillon C, Levenson JW, Sesso HD, Fiore LD, Gaziano JM. Health care utilization and receipt of cholesterol testing by veterans with and those without mental illness. Gen Hosp Psychiatry. 2006 Mar-Apr; 28(2):137-44. 85. Sesso HD. Carotenoids and cardiovascular disease: what research gaps remain? Curr Opin Lipidol. 2006 Feb; 17(1):11-6. 86. Sesso HD, Gaziano JM, Glynn RJ, Buring JE. Value of an Endpoints Committee versus the use of nosologists for validating cause of death. Contemp Clin Trials. 2006 Aug; 27(4):333-9. 87. Weinstein AR, Sesso HD. Joint effects of physical activity and body weight on diabetes and cardiovascular disease. Exerc Sport Sci Rev. 2006 Jan; 34(1):10-5. 88. Bowman TS, Sesso HD, Gaziano JM. Effect of age on blood pressure parameters and risk of cardiovascular death in men. Am J Hypertens. 2006 Jan; 19(1):47-52. 89. Kaplowitz RA, Fagan MJ, Sesso HD, Gaziano JM. Psychiatric disease and hypercholesterolemia in an urban academic primary care clinic. Prim Care Companion J Clin Psychiatry. 2006; 8(2):77-81. 90. Halperin RO, Sesso HD, Ma J, Buring JE, Stampfer MJ, Gaziano JM. Dyslipidemia and the risk of incident hypertension in men. Hypertension. 2006 Jan; 47(1):45-50. 91. Sesso HD, Buring JE, Chown MJ, Ridker PM, Gaziano JM. A prospective study of plasma lipid levels and hypertension in women. Arch Intern Med. 2005 Nov 14; 165(20):2420-7. 92. Song Y, Manson JE, Buring JE, Sesso HD, Liu S. Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. J Am Coll Nutr. 2005 Oct; 24(5):376-84. 93. Kurth T, Hennekens CH, Stürmer T, Sesso HD, Glynn RJ, Buring JE, Gaziano JM. Analgesic use and risk of subsequent hypertension in apparently healthy men. Arch Intern Med. 2005 Sep 12; 165(16):1903-9. 94. Farwell WR, Sesso HD, Buring JE, Gaziano JM. Non-high-density lipoprotein cholesterol versus low-density lipoprotein cholesterol as a risk factor for a first nonfatal myocardial infarction. Am J Cardiol. 2005 Oct 15; 96(8):1129-34. 95. Sesso HD, Buring JE, Zhang SM, Norkus EP, Gaziano JM. Dietary and plasma lycopene and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2005 May; 14(5):1074-81. 96. Oguma Y, Sesso HD, Paffenbarger RS, Lee IM. Weight change and risk of developing type 2 diabetes. Obes Res. 2005 May; 13(5):945-51. 97. Sesso HD, Buring JE, Norkus EP, Gaziano JM. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am J Clin Nutr. 2005 May; 81(5):990-7. 98. Bowman TS, Sesso HD, Glynn RJ, Gaziano JM. JNC 7 category and risk of cardiovascular death in men: are there differences by age? Am J Geriatr Cardiol. 2005 May-Jun; 14(3):126-31; quiz 132-3. 99. Scranton RE, Sesso HD, Glynn RJ, Levenson JW, Stedman M, Gagnon D, Gaziano JM. Characteristics associated with differences in reported versus measured total cholesterol among male physicians. J Prim Prev. 2005 Jan; 26(1):51-61. 100. Liu S, Serdula M, Janket SJ, Cook NR, Sesso HD, Willett WC, Manson JE, Buring JE. A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women. Diabetes Care. 2004 Dec; 27(12):2993-6. 101. Widlansky ME, Sesso HD, Rexrode KM, Manson JE, Gaziano JM. Body mass index and total and cardiovascular mortality in men with a history of cardiovascular disease. Arch Intern Med. 2004 Nov 22; 164(21):2326-32. 102. Lee IM, Sesso HD, Oguma Y, Paffenbarger RS. The "weekend warrior" and risk of mortality. Am J Epidemiol. 2004 Oct 1; 160(7):636-41. 103. Weinstein AR, Sesso HD, Lee IM, Cook NR, Manson JE, Buring JE, Gaziano JM. Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA. 2004 Sep 8; 292(10):1188-94. 104. Scranton R, Sesso HD, Stampfer MJ, Levenson JW, Buring JE, Gaziano JM. Predictors of 14-year changes in the total cholesterol to high-density lipoprotein cholesterol ratio in men. Am Heart J. 2004 Jun; 147(6):1033-8. 105. Zhu K, Lee IM, Sesso HD, Buring JE, Levine RS, Gaziano JM. History of diabetes mellitus and risk of prostate cancer in physicians. Am J Epidemiol. 2004 May 15; 159(10):978-82. 106. Malinski MK, Sesso HD, Lopez-Jimenez F, Buring JE, Gaziano JM. Alcohol consumption and cardiovascular disease mortality in hypertensive men. Arch Intern Med. 2004 Mar 22; 164(6):623-8. 107. Mason PJ, Manson JE, Sesso HD, Albert CM, Chown MJ, Cook NR, Greenland P, Ridker PM, Glynn RJ. Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS). Circulation. 2004 Apr 6; 109(13):1623-9. 108. Sesso HD, Buring JE, Norkus EP, Gaziano JM. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am J Clin Nutr. 2004 Jan; 79(1):47-53. 109. Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM. C-reactive protein and the risk of developing hypertension. JAMA. 2003 Dec 10; 290(22):2945-51. 110. Bowman TS, Sesso HD, Ma J, Kurth T, Kase CS, Stampfer MJ, Gaziano JM. Cholesterol and the risk of ischemic stroke. Stroke. 2003 Dec; 34(12):2930-4. 111. Sesso HD, Chen RS, L'Italien GJ, Lapuerta P, Lee WC, Glynn RJ. Blood pressure lowering and life expectancy based on a Markov model of cardiovascular events. Hypertension. 2003 Nov; 42(5):885-90. 112. Hak AE, Stampfer MJ, Campos H, Sesso HD, Gaziano JM, Willett W, Ma J. Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians. Circulation. 2003 Aug 19; 108(7):802-7. 113. Sesso HD, Paffenbarger RS, Oguma Y, Lee IM. Lack of association between tea and cardiovascular disease in college alumni. Int J Epidemiol. 2003 Aug; 32(4):527-33. 114. Sesso HD, Liu S, Gaziano JM, Buring JE. Dietary lycopene, tomato-based food products and cardiovascular disease in women. J Nutr. 2003 Jul; 133(7):2336-41. 115. Sesso HD, Gaziano JM, Liu S, Buring JE. Flavonoid intake and the risk of cardiovascular disease in women. Am J Clin Nutr. 2003 Jun; 77(6):1400-8. 116. Jackson VA, Sesso HD, Buring JE, Gaziano JM. Alcohol consumption and mortality in men with preexisting cerebrovascular disease. Arch Intern Med. 2003 May 26; 163(10):1189-93. 117. Janket SJ, Manson JE, Sesso H, Buring JE, Liu S. A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care. 2003 Apr; 26(4):1008-15. 118. Lee IM, Sesso HD, Oguma Y, Paffenbarger RS. Physical activity, body weight, and pancreatic cancer mortality. Br J Cancer. 2003 Mar 10; 88(5):679-83. 119. Lee IM, Sesso HD, Oguma Y, Paffenbarger RS. Relative intensity of physical activity and risk of coronary heart disease. Circulation. 2003 Mar 4; 107(8):1110-6. 120. Liu S, Sesso HD, Manson JE, Willett WC, Buring JE. Is intake of breakfast cereals related to total and cause-specific mortality in men? Am J Clin Nutr. 2003 Mar; 77(3):594-9. 121. Sesso HD, Gaziano JM, VanDenburgh M, Hennekens CH, Glynn RJ, Buring JE. Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study. Control Clin Trials. 2002 Dec; 23(6):686-702. 122. Orford JL, Sesso HD, Stedman M, Gagnon D, Vokonas P, Gaziano JM. A comparison of the Framingham and European Society of Cardiology coronary heart disease risk prediction models in the normative aging study. Am Heart J. 2002 Jul; 144(1):95-100. 123. Oguma Y, Sesso HD, Paffenbarger RS, Lee IM. Physical activity and all cause mortality in women: a review of the evidence. Br J Sports Med. 2002 Jun; 36(3):162-72. 124. Liu S, Buring JE, Sesso HD, Rimm EB, Willett WC, Manson JE. A prospective study of dietary fiber intake and risk of cardiovascular disease among women. J Am Coll Cardiol. 2002 Jan 2; 39(1):49-56. 125. Glynn RJ, L'Italien GJ, Sesso HD, Jackson EA, Buring JE. Development of predictive models for long-term cardiovascular risk associated with systolic and diastolic blood pressure. Hypertension. 2002 Jan; 39(1):105-10. 126. Sesso HD, Paffenbarger RS, Lee IM. Alcohol consumption and risk of prostate cancer: The Harvard Alumni Health Study. Int J Epidemiol. 2001 Aug; 30(4):749-55. 127. Sesso HD, Lee IM, Gaziano JM, Rexrode KM, Glynn RJ, Buring JE. Maternal and paternal history of myocardial infarction and risk of cardiovascular disease in men and women. Circulation. 2001 Jul 24; 104(4):393-8. 128. Lee IM, Sesso HD, Paffenbarger RS. A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States). Cancer Causes Control. 2001 Feb; 12(2):187-93. 129. Lee IM, Sesso HD, Chen JJ, Paffenbarger RS. Does physical activity play a role in the prevention of prostate cancer? Epidemiol Rev. 2001; 23(1):132-7. 130. Sesso HD. Alcohol and cardiovascular health: recent findings. Am J Cardiovasc Drugs. 2001; 1(3):167-72. 131. Sesso HD, Stampfer MJ, Rosner B, Hennekens CH, Gaziano JM, Manson JE, Glynn RJ. Systolic and diastolic blood pressure, pulse pressure, and mean arterial pressure as predictors of cardiovascular disease risk in Men. Hypertension. 2000 Nov; 36(5):801-7. 132. Sesso HD, Stampfer MJ, Rosner B, Hennekens CH, Manson JE, Gaziano JM. Seven-year changes in alcohol consumption and subsequent risk of cardiovascular disease in men. Arch Intern Med. 2000 Sep 25; 160(17):2605-12. 133. Sesso HD, Paffenbarger RS, Lee IM. Physical activity and coronary heart disease in men: The Harvard Alumni Health Study. Circulation. 2000 Aug 29; 102(9):975-80. 134. Lee IM, Sesso HD, Paffenbarger RS. Physical activity and coronary heart disease risk in men: does the duration of exercise episodes predict risk? Circulation. 2000 Aug 29; 102(9):981-6. 135. Sesso HD. A drive for the health benefits of walking. Am J Med. 2000 Aug 1; 109(2):160-1. 136. Sesso HD, Stampfer MJ, Rosner B, Gaziano JM, Hennekens CH. Two-year changes in blood pressure and subsequent risk of cardiovascular disease in men. Circulation. 2000 Jul 18; 102(3):307-12. 137. Sesso HD, Paffenbarger RS, Lee IM. Comparison of National Death Index and World Wide Web death searches. Am J Epidemiol. 2000 Jul 15; 152(2):107-11. 138. Gaziano JM, Gaziano TA, Glynn RJ, Sesso HD, Ajani UA, Stampfer MJ, Manson JE, Hennekens CH, Buring JE. Light-to-moderate alcohol consumption and mortality in the Physicians' Health Study enrollment cohort. J Am Coll Cardiol. 2000 Jan; 35(1):96-105. 139. Cole SR, Kawachi I, Sesso HD, Paffenbarger RS, Lee IM. Sense of exhaustion and coronary heart disease among college alumni. Am J Cardiol. 1999 Dec 15; 84(12):1401-5. 140. Gaziano JM, Sesso HD, Breslow JL, Hennekens CH, Buring JE. Relation between systemic hypertension and blood lipids on the risk of myocardial infarction. Am J Cardiol. 1999 Oct 1; 84(7):768-73. 141. Sesso HD, Paffenbarger RS, Ha T, Lee IM. Physical activity and cardiovascular disease risk in middle-aged and older women. Am J Epidemiol. 1999 Aug 15; 150(4):408-16. 142. Lee IM, Sesso HD, Paffenbarger RS. Physical activity and risk of lung cancer. Int J Epidemiol. 1999 Aug; 28(4):620-5. 143. Sesso HD, Gaziano JM. Alcohol intake and cardiovascular morbidity and mortality. Curr Opin Nephrol Hypertens. 1999 May; 8(3):353-7. 144. Sesso HD, Gaziano JM, Buring JE, Hennekens CH. Coffee and tea intake and the risk of myocardial infarction. Am J Epidemiol. 1999 Jan 15; 149(2):162-7. 145. Gaziano JM, Hennekens CH, Godfried SL, Sesso HD, Glynn RJ, Breslow JL, Buring JE. Type of alcoholic beverage and risk of myocardial infarction. Am J Cardiol. 1999 Jan 1; 83(1):52-7. 146. Gaziano JM, Hennekens CH, Satterfield S, Roy C, Sesso HD, Breslow JL, Buring JE. Clinical utility of lipid and lipoprotein levels during hospitalization for acute myocardial infarction. Vasc Med. 1999; 4(4):227-31. 147. Sesso HD, Kawachi I, Vokonas PS, Sparrow D. Depression and the risk of coronary heart disease in the Normative Aging Study. Am J Cardiol. 1998 Oct 1; 82(7):851-6. 148. Sesso HD, Paffenbarger RS, Lee IM. Physical activity and breast cancer risk in the College Alumni Health Study (United States). Cancer Causes Control. 1998 Aug; 9(4):433-9. 149. Sesso HD, Kawachi I. Cigarette advertising on taxicabs in Boston, Massachusetts (USA). Tob Control. 1997; 6(2):128-30.

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