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Ellen W. Seely, MD
Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

Phone: 617-732-5012
Fax: 617-732-5764

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Research Narrative:

Dr. Seely’s research focuses on unique cardiovascular risk factors in women with a focus on the pregnancy complications, preeclampsia and gestational diabetes and menopause. She is studying the mechanisms by which gestational diabetes and preeclampsia lead to increased future cardiovascular risk and how to reduce that risk. In women with prior gestational diabetes, she is studying interventions to reduce the risk of future development of Type 2 diabetes, a cardiovascular risk factor equivalent.  In women with prior preeclampsia, she is studying the role of activation of the angiotensin 2 type-1 receptor in mediating the increased risk for cardiovascular disease.  In postmenopausal women, she has demonstrated complex relationships between both estrogen and progesterone with the renin-angiotensin-aldosterone system, which she postulates may explain in part the increase in CVD associated with hormone treatment in this population.

Dr. Seely directs the Unique Cardiovascular Risk Factors in Women Research and Mentoring Program which is supported by an NIH K-24 Mentoring Award. A goal of the award is to train young investigators in patient oriented research to increase the understanding of unique CVD risk factors in women.

Columbia University College of Physicians and Surgeons, 1981, MD
Brown University, 1977, BA

Publications (Pulled from Harvard Catalyst Profiles):

1. Celi AC, Seely EW, Wang P, Thomas AM, Wilkins-Haug LE. Caring for Women After Hypertensive Pregnancies and Beyond: Implementation and Integration of a Postpartum Transition Clinic. Matern Child Health J. 2019 Jul 01.

2. Rich-Edwards JW, Stuart JJ, Skurnik G, Roche AT, Tsigas E, Fitzmaurice GM, Wilkins-Haug LE, Levkoff SE, Seely EW. Randomized Trial to Reduce Cardiovascular Risk in Women with Recent Preeclampsia. J Womens Health (Larchmt). 2019 Jun 19.

3. Nicklas JM, Rosner BA, Zera CA, Seely EW. Association Between Changes in Postpartum Weight and Waist Circumference and Changes in Cardiometabolic Risk Factors Among Women With Recent Gestational Diabetes. Prev Chronic Dis. 2019 Apr 18; 16:E47.

4. Johns LE, Ferguson KK, McElrath TF, Mukherjee B, Seely EW, Meeker JD. Correction: Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth. PLoS One. 2019; 14(2):e0212950.

5. Noor N, Ferguson KK, Meeker JD, Seely EW, Hauser R, James-Todd T, McElrath TF. Pregnancy phthalate metabolite concentrations and infant birth weight by gradations of maternal glucose tolerance. Int J Hyg Environ Health. 2019 Apr; 222(3):395-401.

6. Enkhmaa D, Tanz L, Ganmaa D, Enkhtur S, Oyun-Erdene B, Stuart J, Chen G, Carr A, Seely EW, Fitzmaurice G, Buyandelger Y, Sarantsetseg B, Gantsetseg G, Rich-Edwards J. Randomized trial of three doses of vitamin D to reduce deficiency in pregnant Mongolian women. EBioMedicine. 2019 Jan; 39:510-519.

7. Noor N, Zong G, Seely EW, Weisskopf M, James-Todd T. Urinary cadmium concentrations and metabolic syndrome in U.S. adults: The National Health and Nutrition Examination Survey 2001-2014. Environ Int. 2018 12; 121(Pt 1):349-356.

8. Nicklas JM, Zera CA, Seely EW. Predictors of very early postpartum weight loss in women with recent gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2018 Jul 22; 1-7.

9. Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR. Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II. Hypertension. 2018 06; 71(6):1083-1090.

10. Honigberg MC, Seely EW, Thomas AM, Lim KH, Parry S, McElrath TF. Infant size and the association between maternal circulating angiogenic factors and preeclampsia. J Perinatol. 2018 05; 38(5):456-461.