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Zongqi Xia, MD, PhD
Associate Neurologist, Brigham and Women's Hospital
Lecturer on Neurology, Part-time, Harvard Medical School

Brigham and Women's Hospital
Department of Neurology
75 Francis Street
Boston, MA 02115

Research Location: Harvard New Research Building


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Research Narrative:

The Laboratory of Translational Neurology and Neuroinflammation aims to build a collaborative clinical and translational research program to address unmet medical challenges in the field of neuroinflammation.  To this end, our team harness multi-dimensional patient-derived information (genomics, transcriptomics, epignomics, microbiome, immune profiling, electronic health records, biometric measurements and neuroimaging phenotypes) and deploy integrative computational and analytical approaches to gain insights into the causes of neuroinflammation and translate these findings into the clinical arena to improve individualized risk prediction, prevention, and management in multiple sclerosis and other disorders of neuroinflammation.

 


Education:
PhD
MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Dhand A, White CC, Johnson C, Xia Z, De Jager PL. A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks. Nat Commun. 2018 09 26; 9(1):3930.

2. Kowalec K, Wright GEB, Drögemöller BI, Aminkeng F, Bhavsar AP, Kingwell E, Yoshida EM, Traboulsee A, Marrie RA, Kremenchutzky M, Campbell TL, Duquette P, Chalasani N, Wadelius M, Hallberg P, Xia Z, De Jager PL, Denny JC, Davis MF, Ross CJD, Tremlett H, Carleton BC. Common variation near IRF6 is associated with IFN-ß-induced liver injury in multiple sclerosis. Nat Genet. 2018 08; 50(8):1081-1085.

3. Manners J, Jadhav AP, Xia Z. Mystery Case: A 61-year-old woman with lower extremity paralysis and sensory loss. Neurology. 2017 11 28; 89(22):e257-e263.

4. Xia Z, Friedlander RM. Minocycline in Multiple Sclerosis - Compelling Results but Too Early to Tell. N Engl J Med. 2017 06 01; 376(22):2191-2193.

5. Xia Z, Steele SU, Bakshi A, Clarkson SR, White CC, Schindler MK, Nair G, Dewey BE, Price LR, Ohayon J, Chibnik LB, Cortese IC, De Jager PL, Reich DS. Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members. JAMA Neurol. 2017 03 01; 74(3):293-300.

6. Bargiela D, Bianchi MT, Westover MB, Chibnik LB, Healy BC, De Jager PL, Xia Z. Selection of first-line therapy in multiple sclerosis using risk-benefit decision analysis. Neurology. 2017 Feb 14; 88(7):677-684.

7. Bove R, Chua AS, Xia Z, Chibnik L, De Jager PL, Chitnis T. Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset. Neurol Genet. 2016 Aug; 2(4):e88.

8. Xia Z, White CC, Owen EK, Von Korff A, Clarkson SR, McCabe CA, Cimpean M, Winn PA, Hoesing A, Steele SU, Cortese IC, Chitnis T, Weiner HL, Reich DS, Chibnik LB, De Jager PL. Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk. Ann Neurol. 2016 Feb; 79(2):178-89.

9. Liao KP, Ananthakrishnan AN, Kumar V, Xia Z, Cagan A, Gainer VS, Goryachev S, Chen P, Savova GK, Agniel D, Churchill S, Lee J, Murphy SN, Plenge RM, Szolovits P, Kohane I, Shaw SY, Karlson EW, Cai T. Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts. PLoS One. 2015; 10(8):e0136651.

10. Liao KP, Cai T, Savova GK, Murphy SN, Karlson EW, Ananthakrishnan AN, Gainer VS, Shaw SY, Xia Z, Szolovits P, Churchill S, Kohane I. Development of phenotype algorithms using electronic medical records and incorporating natural language processing. BMJ. 2015 Apr 24; 350:h1885.