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Richard Steven Blumberg
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Gastroenterology
75 Francis Street
Boston, MA 02115


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Research Narrative:

Dr. Richard S. Blumberg trained in internal medicine (The New York Hospital, 1982), infectious diseases (Massachusetts General Hospital, 1986) and gastroenterology & hepatology (Brigham & Women’s Hospital, 1989). He is currently Senior Physician in Medicine and Gastroenterology at Brigham and Women’s Hospital (BWH) where he leads the Division of Gastroenterology, Hepatology and Endoscopy, is Professor of Medicine at Harvard Medical School and co-Director of the Harvard Digestive Diseases Center. In addition, Dr. Blumberg serves on the Executive Advisory Committee of the Department of Medicine and is the incoming Chair of the Biomedical Research Institute at BWH. He has served as a member of the Immunology Sciences Study Section of NIAID, a member on the National Commission of Digestive Diseases of the NIDDK, scientific consultant to the Human Microbiome Project (NHGRI), a member of the Vaccine Branch External Advisory Board (NCI), Chair of the External Scientific Consultants for the Intestinal Stem Cell Consortium Initiative (NIDDK) and is currently on the Board of Scientific Councilors (NIAID). He served as the Chair of the National Scientific Advisory Committee of the Crohn’s & Colitis of America (2002-2005) and President of the Society for Mucosal Immunology (2007-2009). Dr. Blumberg is an elected member of the American Association of Clinical Investigation and the Association of American Physicians and the recipient of a MERIT Award from the NIH (2005), the William Beaumont Prize from the American Gastroenterological Association (2012) and the Distinguished Scientific Achievement Award from the Crohn’s and Colitis Foundation of America (2012). He is an NIH-funded investigator whose research program focuses on mucosal immunology and was Scientific Founder, Syntonix Pharmaceuticals (now Biogen-Hemophilia) that developed long-acting therapeutic agents successful in the treatment of chronic diseases such as hemophilia A and B.


Publications (Pulled from Harvard Catalyst Profiles):

1. Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS. The Neonatal Fc Receptor (FcRn): A Misnomer? Front Immunol. 2019; 10:1540.

2. Iyer SS, Huang YH, Blumberg RS. SLAM-ing the brakes on iNKT cell selection. Nat Immunol. 2019 04; 20(4):378-379.

3. Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 03 01; 363(6430):993-998.

4. Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole CJ, Lu C, Zhu H, Islam B, Riggelen JV, Browning D, Liu K, Blumberg R, Singh N, Li H. Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019; 5:7.

5. Zeissig S, Blumberg RS. Analyzing Antigen Recognition by Natural Killer T Cells. Methods Mol Biol. 2019; 1988:439-453.

6. Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS. High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Sci Rep. 2018 Nov 30; 8(1):17512.

7. Aires DJ, Yoshida M, Richardson SK, Bai M, Liu L, Moreno R, Lazar AJF, Wick JA, Rich BE, Murphy G, Blumberg RS, Fuhlbrigge RC, Kupper TS. T-cell trafficking plays an essential role in tumor immunity. Lab Invest. 2019 01; 99(1):85-92.

8. Li Y, Guan X, Liu W, Chen HL, Truscott J, Beyatli S, Metwali A, Weiner GJ, Zavazava N, Blumberg RS, Urban JF, Blazar BR, Elliott DE, Ince MN. Helminth-Induced Production of TGF-ß and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells. J Immunol. 2018 11 15; 201(10):2910-2922.

9. Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P. ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. J Exp Med. 2018 Nov 05; 215(11):2868-2886.

10. Berntsen NL, Fosby B, Tan C, Reims HM, Ogaard J, Jiang X, Schrumpf E, Valestrand L, Karlsen TH, Line PD, Blumberg RS, Melum E. Natural killer T cells mediate inflammation in the bile ducts. Mucosal Immunol. 2018 11; 11(6):1582-1590.