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Anthony Arnold Amato, MD
Neurologist, Brigham and Women's Hospital
Professor of Neurology, Harvard Medical School

Brigham and Women's Hospital
Department of Neurology
75 Francis Street
Boston, MA 02115


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Research Narrative:

Investigative Interests: Neuromuscular Disease, Myopathies, Myasthenia Gravis, Peripheral Neuropathy

Much of my research lately has focused on classification and treatment of the inflammatory myopathies and better understanding the pathogenic basis of these disorders.  Below are my active research trials:

  • NeuroNEXT (NIH); Role: Co-PI
  • A Phase 2 Open-label Study to Evaluate the Long-term Safety of Sifalimumab in Adult Subjects with Systemic Lupus Erythematosus or Myositis; Role: Medical Advisory Board and Site PI
  • A Multi-centre, Double-blind, Placebo-controlled, Proof Of Concept Study To Evaluate The Efficacy And Tolerability of BAF312 In patients with Polymyositis and Dermatomyositis; Role: Site PI
  • A double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of BYM338 in patients with sporadic Inclusion Body Myositis; Role: Site co-I
  • Genetic Determinants of Neuropathic Pain; Role: PI
  • Monitoring Novel Influenza A (H1N1) Influenza Vaccine Safety in the Vaccine Safety Datalink; Role: Medical Advisor and Co-I
  • Thymectomy in Myasthenia Gravis; Role: site PI
  • Biomarkers in Myasthenia Gravis; Role: site PI

Education:
MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Hanna MG, Badrising UA, Benveniste O, Lloyd TE, Needham M, Chinoy H, Aoki M, Machado PM, Liang C, Reardon KA, de Visser M, Ascherman DP, Barohn RJ, Dimachkie MM, Miller JAL, Kissel JT, Oskarsson B, Joyce NC, Van den Bergh P, Baets J, De Bleecker JL, Karam C, David WS, Mirabella M, Nations SP, Jung HH, Pegoraro E, Maggi L, Rodolico C, Filosto M, Shaibani AI, Sivakumar K, Goyal NA, Mori-Yoshimura M, Yamashita S, Suzuki N, Katsuno M, Murata K, Nodera H, Nishino I, Romano CD, Williams VSL, Vissing J, Auberson LZ, Wu M, de Vera A, Papanicolaou DA, Amato AA. Safety and efficacy of intravenous bimagrumab in inclusion body myositis (RESILIENT): a randomised, double-blind, placebo-controlled phase 2b trial. Lancet Neurol. 2019 Sep; 18(9):834-844.

2. Olivier PA, De Paepe B, Aronica E, Berfelo F, Colman R, Amato A, Dimitri D, Gallardo E, Gherardi R, Goebel HH, Hilton-Jones D, Hofer M, Holton J, Daa Schrøder H, Selcen D, Stenzel W, de Visser M, De Bleecker JL. Idiopathic inflammatory myopathy: Interrater variability in muscle biopsy reading. Neurology. 2019 Jul 29.

3. Greenberg SA, Pinkus JL, Kong SW, Baecher-Allan C, Amato AA, Dorfman DM. Highly differentiated cytotoxic T cells in inclusion body myositis. Brain. 2019 Jul 20.

4. Ramdharry G, Morrow J, Hudgens S, Skorupinska I, Gwathmey K, Currence M, Herbelin L, Jawdat O, Pasnoor M, Mcvey A, Barohn RJ, Burns TM, Dimachkie MM, Amato AA, Hanna MG, Machado PM. Investigation of the psychometric properties of the inclusion body myositis functional rating scale with rasch analysis. Muscle Nerve. 2019 Aug; 60(2):161-168.

5. Gonzalez-Perez P, Torre M, Helgager J, Amato AA. Proximal muscle weakness. Pract Neurol. 2019 Aug; 19(4):321-325.

6. Wolfe GI, Kaminski HJ, Aban IB, Minisman G, Kuo HC, Marx A, Ströbel P, Mazia C, Oger J, Cea JG, Heckmann JM, Evoli A, Nix W, Ciafaloni E, Antonini G, Witoonpanich R, King JO, Beydoun SR, Chalk CH, Barboi AC, Amato AA, Shaibani AI, Katirji B, Lecky BRF, Buckley C, Vincent A, Dias-Tosta E, Yoshikawa H, Waddington-Cruz M, Pulley MT, Rivner MH, Kostera-Pruszczyk A, Pascuzzi RM, Jackson CE, Verschuuren JJGM, Massey JM, Kissel JT, Werneck LC, Benatar M, Barohn RJ, Tandan R, Mozaffar T, Silvestri NJ, Conwit R, Sonett JR, Jaretzki A, Newsom-Davis J, Cutter GR. Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial. Lancet Neurol. 2019 Mar; 18(3):259-268.

7. Ting BL, Blazar PE, Collins JE, Mora AN, Salajegheh MK, Amato AA, Earp BE. Median Nerve Ultrasonography Measurements Correlate With Electrodiagnostic Carpal Tunnel Syndrome Severity. J Am Acad Orthop Surg. 2019 Jan 01; 27(1):e17-e23.

8. McGrath ER, Doughty CT, Amato AA. Autoimmune Myopathies: Updates on Evaluation and Treatment. Neurotherapeutics. 2018 10; 15(4):976-994.

9. Binda GA, Mataloni F, Bruzzone M, Carabotti M, Cirocchi R, Nascimbeni R, Gambassi G, Amato A, Vettoretto N, Pinnarelli L, Cuomo R, Annibale B. Trends in hospital admission for acute diverticulitis in Italy from 2008 to 2015. Tech Coloproctol. 2018 08; 22(8):597-604.

10. Tran T, Guardigni V, Pencina KM, Amato AA, Floyd M, Brawley B, Mozeleski B, McKinnon J, Woodbury E, Heckel E, Li Z, Storer T, Sax PE, Montano M. Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults. Clin Infect Dis. 2018 Jun 01; 66(12):1918-1927.