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Anthony Arnold Amato, MD
Neurologist, Brigham and Women's Hospital
Professor of Neurology, Harvard Medical School

Brigham and Women's Hospital
Department of Neurology
75 Francis Street
Boston, MA 02115


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Research Narrative:

Investigative Interests: Neuromuscular Disease, Myopathies, Myasthenia Gravis, Peripheral Neuropathy

Much of my research lately has focused on classification and treatment of the inflammatory myopathies and better understanding the pathogenic basis of these disorders.  Below are my active research trials:

  • NeuroNEXT (NIH); Role: Co-PI
  • A Phase 2 Open-label Study to Evaluate the Long-term Safety of Sifalimumab in Adult Subjects with Systemic Lupus Erythematosus or Myositis; Role: Medical Advisory Board and Site PI
  • A Multi-centre, Double-blind, Placebo-controlled, Proof Of Concept Study To Evaluate The Efficacy And Tolerability of BAF312 In patients with Polymyositis and Dermatomyositis; Role: Site PI
  • A double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of BYM338 in patients with sporadic Inclusion Body Myositis; Role: Site co-I
  • Genetic Determinants of Neuropathic Pain; Role: PI
  • Monitoring Novel Influenza A (H1N1) Influenza Vaccine Safety in the Vaccine Safety Datalink; Role: Medical Advisor and Co-I
  • Thymectomy in Myasthenia Gravis; Role: site PI
  • Biomarkers in Myasthenia Gravis; Role: site PI

Education:
MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Wolfe GI, Kaminski HJ, Aban IB, Minisman G, Kuo HC, Marx A, Ströbel P, Mazia C, Oger J, Cea JG, Heckmann JM, Evoli A, Nix W, Ciafaloni E, Antonini G, Witoonpanich R, King JO, Beydoun SR, Chalk CH, Barboi AC, Amato AA, Shaibani AI, Katirji B, Lecky BRF, Buckley C, Vincent A, Dias-Tosta E, Yoshikawa H, Waddington-Cruz M, Pulley MT, Rivner MH, Kostera-Pruszczyk A, Pascuzzi RM, Jackson CE, Verschuuren JJGM, Massey JM, Kissel JT, Werneck LC, Benatar M, Barohn RJ, Tandan R, Mozaffar T, Silvestri NJ, Conwit R, Sonett JR, Jaretzki A, Newsom-Davis J, Cutter GR. Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial. Lancet Neurol. 2019 Mar; 18(3):259-268.

2. Ting BL, Blazar PE, Collins JE, Mora AN, Salajegheh MK, Amato AA, Earp BE. Median Nerve Ultrasonography Measurements Correlate With Electrodiagnostic Carpal Tunnel Syndrome Severity. J Am Acad Orthop Surg. 2019 Jan 01; 27(1):e17-e23.

3. McGrath ER, Doughty CT, Amato AA. Autoimmune Myopathies: Updates on Evaluation and Treatment. Neurotherapeutics. 2018 10; 15(4):976-994.

4. Binda GA, Mataloni F, Bruzzone M, Carabotti M, Cirocchi R, Nascimbeni R, Gambassi G, Amato A, Vettoretto N, Pinnarelli L, Cuomo R, Annibale B. Trends in hospital admission for acute diverticulitis in Italy from 2008 to 2015. Tech Coloproctol. 2018 08; 22(8):597-604.

5. Tran T, Guardigni V, Pencina KM, Amato AA, Floyd M, Brawley B, Mozeleski B, McKinnon J, Woodbury E, Heckel E, Li Z, Storer T, Sax PE, Montano M. Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults. Clin Infect Dis. 2018 Jun 01; 66(12):1918-1927.

6. Amato AA, Baskin PK, Gross RA. Updating Neurology® authorship criteria: Ensuring inclusion of those making valuable intellectual contributions. Neurology. 2018 May 08; 90(19):865-866.

7. Foster LA, Amato AA, Berkowitz AL. Clinical Reasoning: A 60-year-old man with arm weakness and numbness. Neurology. 2018 Jan 23; 90(4):190-196.

8. Bottai M, Tjärnlund A, Santoni G, Werth VP, Pilkington C, de Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Danko K, Dimachkie MM, Feldman BM, García-De La Torre I, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinka M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O'Callaghan A, Wook Song Y, Vencovsky J, Ytterberg SR, Miller FW, Rider LG, Lundberg IE. EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report. RMD Open. 2017; 3(2):e000507.

9. Rider LG, Ruperto N, Pistorio A, Erman B, Bayat N, Lachenbruch PA, Rockette H, Feldman BM, Huber AM, Hansen P, Oddis CV, Lundberg IE, Amato AA, Chinoy H, Cooper RG, Chung L, Danko K, Fiorentino D, García-De la Torre I, Reed AM, Wook Song Y, Cimaz R, Cuttica RJ, Pilkington CA, Martini A, van der Net J, Maillard S, Miller FW, Vencovsky J, Aggarwal R. 2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects. Rheumatology (Oxford). 2017 11 01; 56(11):1884-1893.

10. Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, Visser M, Alfredsson L, Amato AA, Barohn RJ, Liang MH, Singh JA, Aggarwal R, Arnardottir S, Chinoy H, Cooper RG, Dankó K, Dimachkie MM, Feldman BM, Torre IG, Gordon P, Hayashi T, Katz JD, Kohsaka H, Lachenbruch PA, Lang BA, Li Y, Oddis CV, Olesinska M, Reed AM, Rutkowska-Sak L, Sanner H, Selva-O'Callaghan A, Song YW, Vencovsky J, Ytterberg SR, Miller FW, Rider LG. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017 12; 76(12):1955-1964.