Skip to contents

Gail Kurr Adler, Ph.D., MD
Associate Physician, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

Edit Profile

Research Narrative:

Dr. Adler is studying the role of the mineralocorticoid receptor (MR) in cardiovascular pathology.Recent data from her laboratory and others document thatMR activation is associated with cardiac hypertrophy, fibrosis, nephropathy and strokes in experimental animals. Her research is directed at elucidating the molecular and cellular mechanisms underlying these effects using several animal models: 1) nitric oxide synthase inhibition with ANGlI and dietary Na+ supplementation; 2) uni-nephrectomy with aldosterone and dietary Na+ supplementation; 3) streptozotocin treatment (a model of type 1 diabetes mellitus); 4) the db/db mouse (a model of type 2 diabetes mellitus); 5) several genetically manipulated mouse models. Experiments are being conducted to define the role of modulators and/or intermediaries of MR-induced cardiovasculardamage,including estradiol,ANGlI, PAl-l, and the receptor for advanced glycosylation end products.Finally, these laboratory based studies provide ascientificfoundation for studiesbeing conductedin patientsto determine the effects of MR antagonists on renovascular and cardiovascular function in diabetes.

New York University Graduate School of Arts and Sciences, 1982, Ph.D.
New York University School Of Medicine, 1981, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Bogorodskaya M, Fitch KV, Burdo TH, Maehler P, Easly RM, Murray GR, Feldpausch M, Adler GK, Grinspoon SK, Srinivasa S. Serum Lipocalin-2/NGAL in Relation to Biomarkers of Inflammation and Cardiac Stretch During Activation of the Renin-Angiotensin-Aldosterone System (RAAS) in HIV. J Infect Dis. 2019 Jul 11.

2. Haas AV, Hopkins PN, Brown NJ, Pojoga LH, Williams JS, Adler GK, Williams GH. Higher urinary cortisol levels associate with increased cardiovascular risk. Endocr Connect. 2019 Jun 01; 8(6):634-640.

3. Brooks DL, Garza AE, Katayama IA, Romero JR, Adler GK, Pojoga LH, Williams GH. Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice. Endocrinology. 2019 Apr 01; 160(4):716-728.

4. Huang Y, Ting PY, Yao TM, Homma T, Brooks D, Katayama Rangel I, Adler GK, Romero JR, Williams JS, Pojoga LH, Williams GH. Histone demethylase LSD1 deficiency and biological sex: impact on blood pressure and aldosterone production. J Endocrinol. 2019 Feb 01; 240(2):111-122.

5. Vaidya A, Mulatero P, Baudrand R, Adler GK. The Expanding Spectrum of Primary Aldosteronism: Implications for Diagnosis, Pathogenesis, and Treatment. Endocr Rev. 2018 12 01; 39(6):1057-1088.

6. Young MJ, Adler GK. Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease. Vitam Horm. 2019; 109:361-385.

7. Haas AV, Rosner BA, Kwong RY, Rao AD, Garg R, Di Carli MF, Adler GK. Sex Differences in Coronary Microvascular Function in Individuals With Type 2 Diabetes. Diabetes. 2019 03; 68(3):631-636.

8. Srinivasa S, Fitch KV, Quadri N, Maehler P, O'Malley TK, Martinez-Salazar EL, Burdo TH, Feldpausch M, Torriani M, Adler GK, Grinspoon SK. Significant Association of Aldosterone and Liver Fat Among HIV-Infected Individuals With Metabolic Dysregulation. J Endocr Soc. 2018 Oct 01; 2(10):1147-1157.

9. Wu D, Hu D, Chen H, Shi G, Fetahu IS, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian CG, Murphy GF, Adler GK, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 2018 07; 559(7715):637-641.

10. Srinivasa S, Aulinas A, O'Malley T, Maehler P, Adler GK, Grinspoon SK, Lawson EA. Oxytocin response to controlled dietary sodium and angiotensin II among healthy individuals. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E671-E675.