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Edward Meigs Brown, MD
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

Brown's research focuses on how diverse cell types sense the extracellular calcium concentration (Ca2+o) and on the role of Ca2+o as an extracellular first messenger in health and disease. An adequate supply of calcium is a critical for skeletal health, and calcium also serves as a key intracellular second messenger to regulate the function of essentially all cells. More than a decade ago, Dr. Brown cloned an extracellular calcium-sensing receptor (CaR), which proved that calcium could also serve as an extracellular messenger. This receptor is present in many of the cells that sense Ca2+ but relevant to this training program are kidney cells, vascular tissue and cells within the brain. Ongoing projects include studies of the receptor's role in the various tissues expressing it, including pursuit of his intriguing recent findings suggesting that the CaR, MR and ANGII type 1 receptor are co-localized with caveolin 1 in vascular smooth muscle and endothelial cells with unclear functional significance.

Investigative Interests: Calcium, Calcium-sensing receptor, Autoimmunity, Activating Mutation, Inactivating Mutation