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Jeffrey Michael Karp, PhD
Bioengineer, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Renal
75 Francis Street
Boston, MA 02115

Research Location: 65 Lansdowne Street

Phone: (617) 817-9174
Research Email: jmkarp@partners.org



Education:
Massachusetts Institute of Technology (with Bob Langer), 2004-2007, Postdoctoral Fellow
University of Toronto, 2004, Ph.D.
McGill University , 1999, B.Eng.

Honors/Awards:
2011 Society For Biomaterials Young Investigator Award
2009 Gecko Adhesive Technology selected by Popular Mechanics Top 10 Next Medical Breakthrough
2008 TR35 – Recognized as one of the world’s top innovators under age 35, Technology Review-MIT
2010 Coulter Foundation Translational Young Investigator Award
2013 Elected to the American Institute for Medical and Biological Engineering's College of Fellows
2011 Champion in Healthcare, “Innovator” by Boston Business Journal
2010 HST McMahon Mentoring award– top mentor among all faculty who mentor Harvard/MIT students

Publications (Pulled from Harvard Catalyst Profiles):

1. Holmberg FE, Seidelin JB, Yin X, Mead BE, Tong Z, Li Y, Karp JM, Nielsen OH. Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease. EMBO Mol Med. 2017 May; 9(5):558-570.

2. Qasaimeh MA, Wu YC, Bose S, Menachery A, Talluri S, Gonzalez G, Fulciniti M, Karp JM, Prabhala RH, Karnik R. Isolation of Circulating Plasma Cells in Multiple Myeloma Using CD138 Antibody-Based Capture in a Microfluidic Device. Sci Rep. 2017 Apr 04; 7:45681.

3. Seong KY, Seo MS, Hwang DY, O'Cearbhaill ED, Sreenan S, Karp JM, Yang SY. A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin. J Control Release. 2017 Mar 24.

4. Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC. Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Anti-Tumor Innate Immunity. Cancer Discov. 2017 Mar 08.

5. McLean WJ, Yin X, Lu L, Lenz DR, McLean D, Langer R, Karp JM, Edge AS. Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. Cell Rep. 2017 Feb 21; 18(8):1917-1929.

6. Yang Z, Concannon J, Ng KS, Seyb K, Mortensen LJ, Ranganath S, Gu F, Levy O, Tong Z, Martyn K, Zhao W, Lin CP, Glicksman MA, Karp JM. Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation. Sci Rep. 2016 Jul 26; 6:30263.

7. Ranganath SH, Tong Z, Levy O, Martyn K, Karp JM, Inamdar MS. Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering. Stem Cell Reports. 2016 Jun 14; 6(6):926-39.

8. Levy O, Brennen WN, Han E, Rosen DM, Musabeyezu J, Safaee H, Ranganath S, Ngai J, Heinelt M, Milton Y, Wang H, Bhagchandani SH, Joshi N, Bhowmick N, Denmeade SR, Isaacs JT, Karp JM. A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. Biomaterials. 2016 Jun; 91:140-50.

9. Fischer SC, Levy O, Kroner E, Hensel R, Karp JM, Arzt E. Bioinspired polydimethylsiloxane-based composites with high shear resistance against wet tissue. J Mech Behav Biomed Mater. 2016 Aug; 61:87-95.

10. Yin X, Mead BE, Safaee H, Langer R, Karp JM, Levy O. Engineering Stem Cell Organoids. Cell Stem Cell. 2016 Jan 07; 18(1):25-38.