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Elliot Israel, MD
Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Pulmonary
75 Francis Street
Boston, MA 02115


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Research Narrative:

Dr. Elliot Israel is Professor of Medicine at Harvard Medical School in Boston, Massachusetts. He is Director of Clinical Research in the Pulmonary Division. He was honored with the Daniel D. Federman Outstanding Clinical Educator Award by Harvard Medical School.  Dr. Israel’s major research interests include mediators of airway reactivity, biomarkers of asthma, therapeutic interventions to improve asthma outcomes, pharmacogenomics, and approaches to understanding and minimizing disparities in asthma morbidity. He has several grants from the National Institutes of Health to study asthma, severe asthma,  and leads one of 8 sites throughout the country supported by the NIH to conduct research into better asthma treatments. He is interested in disparities in asthma outcomes among minority and disadvantaged populations. He has conducted, and is conducting, studies in African Americans with asthma. These studies have involved investigating genetic determinants of differentiated responses to medications and the effectiveness of individualized therapeutic approaches in this population.  He was named one of Boston’s best in Pulmonary Medicine by Boston Magazine. He has authored or coauthored more than 125 articles, reviews, and abstracts in such journals as the New England Journal of Medicine, JAMA, American Journal of Respiratory and Critical Care Medicine, Journal of Allergy and Clinical Immunology, and The Lancet. Dr. Israel received his medical degree and completed his internship at Johns Hopkins University School of Medicine in Baltimore, Maryland. After completing his residency at New York Hospital/Cornell Medical College in New York City, he obtained clinical and research fellowships in both Pulmonary and Critical Care Medicine and Allergy and Immunology from Brigham and Women’s Hospital and Harvard Medical School in Boston.


Education:
Johns Hopkins University School of Medicine, 1979, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Kim SH, Mitchel JA, McGill M, Cremona TP, Baek JW, Kasahara DI, Anathy V, Israel E, Park JA. Elevated extracellular maspin after mechanical compression in vitro or allergen challenges in vivo. J Allergy Clin Immunol. 2019 Jun 19.

2. Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE. Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma. Am J Respir Crit Care Med. 2019 Jun 01; 199(11):1358-1367.

3. Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 05 23; 380(21):2009-2019.

4. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 May 01; 199(9):1076-1085.

5. Casale TB, Israel E. Biologics, Clinical Context, and the Asthmas. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1437-1439.

6. Cahill KN, Cui J, Kothari P, Murphy K, Raby BA, Singer J, Israel E, Boyce JA, Laidlaw TM. Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial. Am J Respir Crit Care Med. 2019 Apr 12.

7. Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 Mar 11.

8. Ramadan AA, Gaffin JM, Israel E, Phipatanakul W. Asthma and Corticosteroid Responses in Childhood and Adult Asthma. Clin Chest Med. 2019 Mar; 40(1):163-177.

9. Kankaanranta H, Israel E. What Patients Can Tell Us About Their Asthma. J Allergy Clin Immunol Pract. 2019 Mar; 7(3):906-907.

10. Guilbert TW, Bacharier LB, Mauger DT, Phipatanakul W, Szefler SJ, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana MD, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF, Ly N, Meade K, Morgan W, Moy J, Olin JT, Peters SP, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Teague WG, Thyne S, Martinez FD. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children. J Allergy Clin Immunol. 2019 May; 143(5):1934-1937.e4.