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Jacqueline Suk Danik, MD, DrPH
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Preventive Medicine
75 Francis Street
Boston, MA 02115


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Research Narrative:

Dr. Jacqueline S. Danik, is epidemiologist and cardiologist.  Dr. Danik’s research interests include identification of mediators of cardiovascular disease risk, and she works in the areas of inflammation, lipids and metabolism.  As a recipient of a career development award from the National Heart, Lung, and Blood Institute to investigate the biologic basis of inflammatory biomarkers that relate to cardiovascular disease risk, Dr. Danik is also interested in evaluating the genetic basis of heritable risk factors for cardiovascular disease.  

In her work, she has shown that genes related to metabolism determine circulating C-reactive protein levels, and quantified risk of vascular disease that is associated with elevation of heritable factors such as lipoprotein (a).  Other research interests include identification of pathways that predict both beneficial and adverse response to therapies such as statin therapy for cardiovascular disease prevention.  Dr. Danik is also a recipient of an award from the American Heart Association to evaluate the interrelationship of adiposity, vitamin D supplementation and cardiovascular disease risk factors in the ongoing VITAmin D and Omega-3 Trial (VITAL) randomized clinical trial being run in Preventive Medicine at Brigham and Women’s Hospital.  In addition to leading this study in VITAL that investigates the impact of vitamin D supplementation on indices of adiposity, she serves as the medical safety officer for the VITAL trial and as the chairperson of its cardiovascular endpoint committee. 

She completed her cardiovascular medicine fellowship at Brigham and Women’s Hospital and is a graduate of Harvard Medical School.


Education:
Harvard School of Public Health, DrPH
Brigham and Women's Hospital, Cardiology
Harvard School of Public Health, MPH
Columbia Presbyterian Hospital, Residency
Harvard Medical School, MD
Harvard College, BA

Publications (Pulled from Harvard Catalyst Profiles):

1. Kumar S, Danik SB, Altman RK, Barrett CD, Lip GY, Chatterjee S, Roubin GS, Natale A, Danik JS. Non-Vitamin K Antagonist Oral Anticoagulants and Antiplatelet Therapy for Stroke Prevention in Patients With Atrial Fibrillation: A Meta-Analysis of Randomized Controlled Trials. Cardiol Rev. 2016 Sep-Oct; 24(5):218-23.

2. Chandler PD, Wang L, Zhang X, Sesso HD, Moorthy MV, Obi O, Lewis J, Prince RL, Danik JS, Manson JE, LeBoff MS, Song Y. Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2015 Sep; 73(9):577-93.

3. Chatterjee S, Krishnamoorthy P, Ranjan P, Roy A, Chakraborty A, Sabharwal MS, Ro R, Agarwal V, Sardar P, Danik J, Giri JS, DeGoma EM, Kumbhani DJ. Statins and cognitive function: an updated review. Curr Cardiol Rep. 2015 Feb; 17(2):4.

4. Danik JS, Chasman DI, MacFadyen JG, Nyberg F, Barratt BJ, Ridker PM. Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy. Am Heart J. 2013 Jun; 165(6):1008-14.

5. Danik JS, Buring JE, Chasman DI, Zee RY, Ridker PM, Glynn RJ. Lipoprotein(a), polymorphisms in the LPA gene, and incident venous thromboembolism among 21483 women. J Thromb Haemost. 2013 Jan; 11(1):205-8.

6. Danik JS, Manson JE. Vitamin d and cardiovascular disease. Curr Treat Options Cardiovasc Med. 2012 Aug; 14(4):414-24.

7. Ridker PM, Paynter NP, Danik JS, Glynn RJ. Interpretation of Mendelian randomization studies and the search for causal pathways in atherothrombosis: the need for caution. Metab Syndr Relat Disord. 2010 Dec; 8(6):465-9.

8. Danik JS, Paré G, Chasman DI, Zee RY, Kwiatkowski DJ, Parker A, Miletich JP, Ridker PM. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. Circ Cardiovasc Genet. 2009 Apr; 2(2):134-41.

9. Suk Danik J, Rifai N, Buring JE, Ridker PM. Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular events. J Am Coll Cardiol. 2008 Jul 08; 52(2):124-31.

10. Ridker PM, Pare G, Parker A, Zee RY, Danik JS, Buring JE, Kwiatkowski D, Cook NR, Miletich JP, Chasman DI. Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet. 2008 May; 82(5):1185-92.