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J. Michael Gaziano, MD, MPH
Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Division of Aging
75 Francis Street
Boston, MA 02115


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Research Narrative:

Principal Investigator, Million Veteran Program and Scientific Director of the Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Heathcare System; Chief, Division of Aging, Brigham and Women's Hospital, Professor of Medicine, Harvard Medical School; all in Boston, Massachusetts

 

Dr. Gaziano is a preventive cardiologist and internationally recognized chronic disease epidemiologist whose research interests include the epidemiology of chronic diseases using large data sources. He has a particular interest in the lifestyle, metabolic, biochemical and genetic determinants of common chronic disease such as cardiovascular disease and cancer.

 

A centerpiece of his research involves the conduct of observational studies and trials that are imbedded in a health care system and the curation of electronic health data from many sources. He serves as one of two PIs of the Million Veteran Program (MVP), a project that will enroll one million veterans into a longitudinal cohort with stored biospecimens, self-reported data and the rich electronic clinical and administrative data available in the VA. To date over 650,000 veterans have been enrolled into MVP. He is principal investigator of the Physicians' Health Study, a large-scale trial-based cohort of over 29,000 physicians followed for over 30 years. He has also served as PI, Co-PI or co-investigator on a number of other cohort studies and large-scale trials. He serves on advisory committees for the Precision Medicine Initiative and the UKBiobank.

 

Dr. Gaziano oversees several fellowship programs and teaches advanced epidemiology at the Harvard School of Public Health. He has published over 600 journal articles, reviews, book chapters and books. He has also served as an Associate Editor for the Journal of the American Medical Association. He is a Fellow of the Royal College of Physicians.

 

Education:
Harvard School of Public Health, 1993, MPH
Yale University School of Medicine, 1987, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Bodar V, Chen J, Gaziano JM, Albert C, Djoussé L. Coffee Consumption and Risk of Atrial Fibrillation in the Physicians' Health Study. J Am Heart Assoc. 2019 Aug 06; 8(15):e011346.

2. Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans. Nat Neurosci. 2019 Jul 29.

3. Bick AG, Akwo E, Robinson-Cohen C, Lee K, Lynch J, Assimes TL, DuVall S, Edwards T, Fang H, Freiberg SM, Giri A, Huffman JE, Huang J, Hull L, Kember RL, Klarin D, Lee JS, Levin M, Miller DR, Natarajan P, Saleheen D, Shao Q, Sun YV, Tang H, Wilson O, Chang KM, Cho K, Concato J, Gaziano JM, Kathiresan S, O'Donnell CJ, Rader DJ, Tsao PS, Wilson PW, Hung AM, Damrauer SM. Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program. Circulation. 2019 Jul 24.

4. Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A, Sun YV, Vujkovic M, Freiberg MS, Wang L, Chen J, Saleheen D, Lee JS, Miller DR, Reaven P, Alba PR, Patterson OV, DuVall SL, Boden WE, Beckman JA, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, O'Donnell CJ, Kathiresan S, Tsao PS, Damrauer SM. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med. 2019 Aug; 25(8):1274-1279.

5. Huang JY, Larose TL, Luu HN, Wang R, Fanidi A, Alcala K, Stevens VL, Weinstein SJ, Albanes D, Caporaso NE, Purdue MP, Ziegler RG, Freedman ND, Lan Q, Prentice RL, Pettinger M, Thomson CA, Cai Q, Wu J, Blot WJ, Shu XO, Zheng W, Arslan AA, Zeleniuch-Jacquotte A, Le Marchand L, Wilkens LR, Haiman CA, Zhang X, Stampfer MJ, Han J, Giles GG, Hodge AM, Severi G, Johansson M, Grankvist K, Langhammer A, Hveem K, Xiang YB, Li HL, Gao YT, Visvanathan K, Ueland PM, Midttun Ø, Ulvi A, Buring JE, Lee IM, Sesso HD, Gaziano JM, Manjer J, Relton C, Koh WP, Brennan P, Johansson M, Yuan JM. Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). Int J Cancer. 2019 Jul 05.

6. Harrington KM, Nguyen XT, Song RJ, Hannagan K, Quaden R, Gagnon DR, Cho K, Deen JE, Muralidhar S, O'Leary TJ, Gaziano JM, Whitbourne SB. Gender Differences in Demographic and Health Characteristics of the Million Veteran Program Cohort. Womens Health Issues. 2019 06 25; 29 Suppl 1:S56-S66.

7. Honerlaw JP, Ho YL, Nguyen XT, Cho K, Vassy JL, Gagnon DR, O'Donnell CJ, Gaziano JM, Wilson PWF, Djousse L. Fried food consumption and risk of coronary artery disease: The Million Veteran Program. Clin Nutr. 2019 Jun 05.

8. Seidu S, Kunutsor SK, Sesso HD, Gaziano JM, Buring JE, Roncaglioni MC, Khunti K. Aspirin has potential benefits for primary prevention of cardiovascular outcomes in diabetes: updated literature-based and individual participant data meta-analyses of randomized controlled trials. Cardiovasc Diabetol. 2019 Jun 03; 18(1):70.

9. Matsumoto C, Yoruk A, Wang L, Gaziano JM, Sesso HD. Fish and omega-3 fatty acid consumption and risk of hypertension. J Hypertens. 2019 Jun; 37(6):1223-1229.

10. McGee EE, Jackson SS, Petrick JL, Van Dyke AL, Adami HO, Albanes D, Andreotti G, Beane-Freeman LE, de Gonzalez AB, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon R, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, Zhu B, McGlynn KA, Campbell PT, Koshiol J. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies. J Natl Cancer Inst. 2019 May 24.