Skip to contents

Francine Grodstein, SCD
Epidemiologist, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Channing Division of Network Medicine
75 Francis Street
Boston, MA 02115

Research Email: fgrodstein@partners.org

Edit Profile


Research Narrative:
Dr. Grodstein’s research focuses on healthy aging, particularly in women. Her primary research base is the Nurses’ Health Study (NHS), where she leads a study of cognitive function among the oldest participants. This includes several repeated measures of function in 20,000 women aged 70 years and over. In addition, she leads cognitive substudies within three large-scale randomized clinical trials of vitamin supplements and aspirin with a total of 16,000 participants in the cognitive cohort. 
 
She also is Scientific Director of the Nurses' Health Studies (NHS) overall. The NHS includes over 200,000 women who have been followed for 30+ years, with biennial questionnaires on lifestyle and health, as 
2 well as a biorepository with blood and urine samples from 60,000 of the participants and tumor tissue in 20,000 of the women who developed cancers. The NHS represents a rich source of research for the entire BWH community. 

 

 

Education:
Harvard School of Public Health , 1992, SCD

Publications (Pulled from Harvard Catalyst Profiles):

1. Kim ES, Fong K, Lee L, Spiro A, Schwartz J, Whitsel E, Horvath S, Wang C, Hou L, Baccarelli AA, Li Y, Stewart J, Manson JE, Grodstein F, DeMeo DL, Kubzansky LD. Optimism is not associated with two indicators of DNA methylation aging. Aging (Albany NY). 2019 Jul 18; 11(14):4970-4989.

2. Bynum J, Passow H, Austin A, Carmichael D, Grodstein F. Serious Illness and End-of-Life Treatments for Nurses Compared with the General Population. J Am Geriatr Soc. 2019 Aug; 67(8):1582-1589.

3. Erekson E, Hagan KA, Austin A, Carmichael D, Minassian VA, Grodstein F, Bynum JPW. Outpatient Evaluation and Management Visits for Urinary Incontinence in Older Women. J Urol. 2019 08; 202(2):333-338.

4. Trudel-Fitzgerald C, James P, Kim ES, Zevon ES, Grodstein F, Kubzansky LD. Prospective associations of happiness and optimism with lifestyle over up to two decades. Prev Med. 2019 Jun 18; 126:105754.

5. Kim ES, James P, Zevon ES, Trudel-Fitzgerald C, Kubzansky LD, Grodstein F. Optimism and Healthy Aging in Women and Men. Am J Epidemiol. 2019 Jun 01; 188(6):1084-1091.

6. McGee EE, Jackson SS, Petrick JL, Van Dyke AL, Adami HO, Albanes D, Andreotti G, Beane-Freeman LE, de Gonzalez AB, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon R, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, Zhu B, McGlynn KA, Campbell PT, Koshiol J. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies. J Natl Cancer Inst. 2019 May 24.

7. Jackson SS, Van Dyke AL, Zhu B, Pfeiffer RM, Petrick JL, Adami HO, Albanes D, Andreotti G, Beane Freeman LE, Berrington de González A, Buring JE, Chan AT, Chen Y, Fraser GE, Freedman ND, Gao YT, Gapstur SM, Gaziano JM, Giles GG, Grant EJ, Grodstein F, Hartge P, Jenab M, Kitahara CM, Knutsen SF, Koh WP, Larsson SC, Lee IM, Liao LM, Luo J, McGee EE, Milne RL, Monroe KR, Neuhouser ML, O'Brien KM, Peters U, Poynter JN, Purdue MP, Robien K, Sandler DP, Sawada N, Schairer C, Sesso HD, Simon TG, Sinha R, Stolzenberg-Solomon RZ, Tsugane S, Wang R, Weiderpass E, Weinstein SJ, White E, Wolk A, Yuan JM, Zeleniuch-Jacquotte A, Zhang X, McGlynn KA, Campbell PT, Koshiol J. Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project. Cancer Res. 2019 Aug 01; 79(15):3973-3982.

8. Kim DH, Afilalo J, Shi SM, Popma JJ, Khabbaz KR, Laham RJ, Grodstein F, Guibone K, Lux E, Lipsitz LA. Evaluation of Changes in Functional Status in the Year After Aortic Valve Replacement. JAMA Intern Med. 2019 Mar 01; 179(3):383-391.

9. Devore E, Hall KE, Schernhammer ES, Grodstein F. CE: Original Research: Midlife Hypertension and Hypercholesterolemia in Relation to Cognitive Function Later in Life in Black Women. Am J Nurs. 2019 Feb; 119(2):22-30.

10. Curhan SG, Willett WC, Grodstein F, Curhan GC. Longitudinal study of hearing loss and subjective cognitive function decline in men. Alzheimers Dement. 2019 Apr; 15(4):525-533.