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Jane Ann Driver, MD, MPH
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Division of Aging
75 Francis Street
Boston, MA 02115


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Research Narrative:

Trained as both an oncologist and a geriatrician, Dr. Driver is interested in the prediction and prevention of age-related cancer and neurodegenerative disease. She became a faculty member of the Division of Aging in 2007, following a productive research fellowship. Her early work focused on the epidemiology, risk factors, and mortality of cancer and Parkinson's disease, using the Physicians' Health Study cohort. She has demonstrated a decreased risk of nearly all types of cancer in patients with Parkinson's disease, and is currently pursuing the hypothesis that patients destined to develop Alzheimer's disease also have a decreased risk of cancer. Interestingly, cancer and neurodegenerative diseases share common genes and biological pathways. A deeper understanding of the relationship between these two diseases might lead to new forms of treatment or prevention.

Recently, Dr. Driver broadened the scope of her work to include translational research. Pin1 is a newly described protein that is key to the pathogenesis of both Alzheimer's disease and cancer, which has exciting potential as a biomarker and therapeutic target for both diseases. In collaboration with Dr. Kun Ping Lu, who first described Pin1, she will determine whether genetic variation in the PIN1 gene, or serum levels of the Pin 1 protein, can be used as a biomarker for either disease.


Education:
Harvard University, 2006, MPH
University of Pittsburgh, 1997, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Sager ZS, Buss MK, Hill KP, Driver JA, Skarf LM. Managing Opioid Use Disorder in the Setting of a Terminal Disease: Opportunities and Challenges. J Palliat Med. 2019 Jul 11.

2. Gupta A, Preis SR, Beiser AS, Splansky GL, DeCarli CS, Au R, Driver JA. Relationship of Cancer to Brain Aging Markers of Alzheimer's Disease: The Framingham Heart Study. Adv Geriatr Med Res. 2019; 1.

3. Chen MY, Orkaby AR, Rosenberg MA, Driver JA. Frailty, Implantable Cardioverter Defibrillators, and Mortality: a Systematic Review. J Gen Intern Med. 2019 Jul 01.

4. Regier NG, Naik AD, Mulligan EA, Nasreddine ZS, Driver JA, Sada YH, Moye J. Cancer-related cognitive impairment and associated factors in a sample of older male oral-digestive cancer survivors. Psychooncology. 2019 Jul; 28(7):1551-1558.

5. Liu MA, DuMontier C, Murillo A, Hshieh TT, Bean JF, Soiffer RJ, Stone RM, Abel GA, Driver JA. Gait speed, grip strength, and clinical outcomes in older patients with hematologic malignancies. Blood. 2019 Jul 25; 134(4):374-382.

6. Catalá-López F, Forés-Martos J, Driver JA, Page MJ, Hutton B, Ridao M, Alonso-Arroyo A, Macías Saint-Gerons D, Gènova-Maleras R, Valderas JM, Vieta E, Valencia A, Tabarés-Seisdedos R. Association of Anorexia Nervosa With Risk of Cancer: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019 Jun 05; 2(6):e195313.

7. Reese RL, Clement SA, Syeda S, Hawley CE, Gosian JS, Cai S, Jensen LL, Kind AJH, Driver JA. Coordinated-Transitional Care for Veterans with Heart Failure and Chronic Lung Disease. J Am Geriatr Soc. 2019 Jul; 67(7):1502-1507.

8. DuMontier C, Liu MA, Murillo A, Hshieh T, Javedan H, Soiffer R, Stone RM, Driver JA, Abel GA. Function, Survival, and Care Utilization Among Older Adults With Hematologic Malignancies. J Am Geriatr Soc. 2019 May; 67(5):889-897.

9. Zhu Z, Lin Y, Li X, Driver JA, Liang L. Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis. Hum Genet. 2019 Mar; 138(3):271-285.

10. Orkaby AR, Lunetta KL, Sun FJ, Driver JA, Benjamin EJ, Hamburg NM, Mitchell GF, Vasan RS, Murabito JM. Cross-Sectional Association of Frailty and Arterial Stiffness in Community-Dwelling Older Adults: The Framingham Heart Study. J Gerontol A Biol Sci Med Sci. 2019 Feb 15; 74(3):373-379.