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Research Narrative:

Publications (Pulled from Harvard Catalyst Profiles):

1. Ingwall JS. The energetic cost of contraction is higher in the myocardium of patients with hypertrophic cardiomyopathy. Cardiovasc Res. 2014 Jul 15; 103(2):192-3.

2. Taegtmeyer H, Ingwall JS. Creatine--a dispensable metabolite? Circ Res. 2013 Mar 15; 112(6):878-80.

3. Grossman AN, Opie LH, Beshansky JR, Ingwall JS, Rackley CE, Selker HP. Glucose-insulin-potassium revived: current status in acute coronary syndromes and the energy-depleted heart. Circulation. 2013 Mar 5; 127(9):1040-8.

4. He H, Hoyer K, Tao H, Rice R, Jimenez J, Tardiff JC, Ingwall JS. Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific. J Physiol. 2012 Nov 1; 590(Pt 21):5371-88.

5. Selker HP, Beshansky JR, Griffith JL, D'Agostino RB, Massaro JM, Udelson JE, Rashba EJ, Ruthazer R, Sheehan PR, Desvigne-Nickens P, Rosenberg YD, Atkins JM, Sayah AJ, Aufderheide TP, Rackley CE, Opie LH, Lambrew CT, Cobb LA, Macleod BA, Ingwall JS, Zalenski RJ, Apstein CS. Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndromes in emergency medical services. Am Heart J. 2012 Mar; 163(3):315-22.

6. Pinz I, Zhu M, Mende U, Ingwall JS. An improved isolation procedure for adult mouse cardiomyocytes. Cell Biochem Biophys. 2011 Sep; 61(1):93-101.

7. Dzeja PP, Hoyer K, Tian R, Zhang S, Nemutlu E, Spindler M, Ingwall JS. Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency. J Physiol. 2011 Nov 1; 589(Pt 21):5193-211.

8. Hoyer K, Song Y, Wang D, Phan D, Balschi J, Ingwall JS, Belardinelli L, Shryock JC. Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain. J Pharmacol Exp Ther. 2011 May; 337(2):513-23.

9. Pinz I, Tian R, Belke D, Swanson E, Dillmann W, Ingwall JS. Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a. J Biol Chem. 2011 Mar 25; 286(12):10163-8.

10. Ingwall JS, Shen W. On energy circuits in the failing myocardium. Eur J Heart Fail. 2010 Dec; 12(12):1268-70.