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Elazer Reuven Edelman
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

Dr. Elazer Edelman’s work is directed towards understanding atherosclerotic arterial disease. Both the means by which atherosclerosis is kept in check and the mechanisms that lead to the decompensation that results in unstable coronary syndromes is of significant interest to Dr. Edelman. Using animal models of vascular injury that permit examination of isolated lesions and specific pharmacologic manipulation of individual lesions, Dr. Edelman’s most recent focus has been on the understanding of the blood vessel’s endothelial monolayer and the examination of basic physiology of vascular drug delivery.

Endothelial Monolayer: Studies are underway to understand the endothelial cell (EC) as a bioregulator. Dr. Edelman has determined that local environment and substratum- EC interactions determine EC immune identity and local immune regulation. Therefore, he concludes that the health of the EC is defined not only in terms of density but also by immune modulation.

Vascular Drug Delivery: Dr. Edelman’s studies have determined that the distribution patterns of eluting drugs are found to be dependent on ultrastructural aspects of target vessels, flow over and through vessels, systemic and environmental states, as well as physico-chemical properties of individual drugs. Determination of the impact of arterial composition, geometry and ultrastructure on drug distribution and drug effect is now being studied.

Models of arterial injury and local drug delivery are examined in both the study of the endothelial monolayer and the basic physiology of vascular drug delivery: Studies are monitored using a variety classic and modern techniques in molecular, cell and tissue biology as well as immunocytochemistry to define the nature of cellular response, selective dyes to demonstrate changes in vascular permeability, strength of materials testing to detest changes in elastic properties, and digital signal processing of video images of injected injured arteries to define the different microvascular structures surrounding diseased blood vessels.

Publications (Pulled from Harvard Catalyst Profiles):

1. Tzafriri AR, Mahfoud F, Keating JH, Spognardi AM, Markham PM, Wong G, Highsmith D, O'Fallon P, Fuimaono K, Edelman ER. Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy. Hypertension. 2019 Sep; 74(3):546-554.

2. Mahfoud F, Tschernig T, Edelman ER. Aorticorenal Ganglia Pacing: A Step Forward in Unblinding Renal Denervation Procedures? JACC Cardiovasc Interv. 2019 Jun 24; 12(12):1121-1124.

3. Athanasiou LS, Nezami FR, Edelman ER. Hemodynamic consequences of a multilayer flow modulator in aortic dissection. Med Biol Eng Comput. 2019 Jun 17.

4. Kalluri AS, Vellarikkal SK, Edelman ER, Nguyen L, Subramanian A, Ellinor PT, Regev A, Kathiresan S, Gupta RM. Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations. Circulation. 2019 Jul 09; 140(2):147-163.

5. El-Kurdi M, Soletti L, McGrath J, Linhares S, Rousselle S, Greisler H, Edelman E, Schoen FJ. Functional remodeling of an electrospun polydimethylsiloxane-based polyether urethane external vein graft support device in an ovine model. J Biomed Mater Res A. 2019 Oct; 107(10):2135-2149.

6. Edelman ER, FitzGerald GA. A decade of Science Translational Medicine. Sci Transl Med. 2019 Apr 24; 11(489).

7. Chang BY, Keller SP, Edelman ER. Leveraging device-arterial coupling to determine cardiac and vascular state. IEEE Trans Biomed Eng. 2019 Jan 28.

8. Saemisch M, Balcells M, Riesinger L, Nickmann M, Bhaloo SI, Edelman ER, Methe H. Subendothelial matrix components influence endothelial cell apoptosis in vitro. Am J Physiol Cell Physiol. 2019 Feb 01; 316(2):C210-C222.

9. Olender ML, Athanasiou LS, de la Torre Hernandez JM, Ben-Assa E, Nezami FR, Edelman ER. A Mechanical Approach for Smooth Surface Fitting to Delineate Vessel Walls in Optical Coherence Tomography Images. IEEE Trans Med Imaging. 2019 Jun; 38(6):1384-1397.

10. Athanasiou L, Nezami FR, Edelman ER. Position Paper Computational Cardiology. IEEE J Biomed Health Inform. 2019 01; 23(1):4-11.